1Department of Cardiology and Angiology, University Medical Center Maribor, Maribor, Slovenia.
2Herzzentrum Leipzig, Leipzig, Germany.
J Womens Health (Larchmt). 2019 Jul;28(7):1004-1010. doi: 10.1089/jwh.2018.7211. Epub 2019 Jan 11.
Data are lacking concerning possible age-specific sex-based differences in anemia in myocardial infarction (MI) patients and its association with the outcome. The aim was to assess whether these differences in anemia (on admission and at discharge) in MI patients who underwent percutaneous coronary intervention (PCI) are associated with the outcome. Data from 5579 MI patients (31.0% women) undergoing PCI at our institution were analyzed. Men and women in different age groups were compared regarding anemia and its association with the 30-day and long-term all-cause mortality. Data were analyzed using descriptive statistics. Women suffered anemia more than men (37.5% vs. 26.8%; < 0.0001). The prevalence of anemia increased rapidly with age in men but not in women. A J-shaped relationship between age and anemia was found in women. The lower the age, the greater the difference in the prevalence of anemia between the sexes. The difference in the prevalence of anemia at discharge was even more pronounced. Anemia on admission (odds ratio [OR] = 1.39; 95% confidence interval [CI] = 1.10-1.76; = 0.005) and at discharge (OR = 2.61; 95% CI = 1.98-3.44; < 0.0001) predicted a higher 30-day mortality. Women had a better adjusted long-term prognosis (hazard ratio [HR] = 0.78; 95% CI = 0.69-0.87; < 0.0001) for the total population. Anemia on admission (HR = 1.43; 95% CI = 1.29-1.60; < 0.0001) and at discharge (HR = 1.96; 95% CI = 1.23-2.21; < 0.0001) predicted a higher long-term mortality. Younger women with MI suffer anemia more frequently than their male peers. Anemia was associated with a worse outcome. Age-specific sex-based differences in anemia help to explain the increased sex-related mortality in MI patients undergoing PCI.
数据显示，在接受经皮冠状动脉介入治疗（PCI）的心肌梗死（MI）患者中，贫血可能存在特定年龄的性别差异，但其与结局的关系尚不清楚。本研究旨在评估这些接受 PCI 的 MI 患者的入院时和出院时的贫血差异是否与结局相关。分析了在我院接受 PCI 的 5579 例 MI 患者（31.0%为女性）的数据。比较了不同年龄组的男性和女性的贫血及其与 30 天和长期全因死亡率的关系。使用描述性统计分析数据。女性比男性更容易贫血（37.5%比 26.8%；<0.0001）。男性的贫血患病率随年龄快速增加，而女性则不然。女性贫血与年龄之间存在 J 形关系。年龄越低，两性贫血患病率的差异越大。出院时的贫血差异更为明显。入院时的贫血（优势比[OR] = 1.39；95%置信区间[CI] = 1.10-1.76； = 0.005）和出院时的贫血（OR = 2.61；95% CI = 1.98-3.44； < 0.0001）均预测 30 天死亡率更高。对于总体人群，女性具有更好的长期预后调整（风险比[HR] = 0.78；95% CI = 0.69-0.87； < 0.0001）。入院时的贫血（HR = 1.43；95% CI = 1.29-1.60； < 0.0001）和出院时的贫血（HR = 1.96；95% CI = 1.23-2.21； < 0.0001）均预测长期死亡率更高。年轻的 MI 女性比同龄男性更容易发生贫血。贫血与不良结局相关。年龄特异性的性别差异有助于解释接受 PCI 的 MI 患者中与性别相关的死亡率增加。
