J Assoc Nurses AIDS Care. 2019 Sep-Oct;30(5):556-562. doi: 10.1097/JNC.0000000000000045.
The aim of our study was to explore the relationships between physical activity, depression, and antiretroviral therapy (ART) adherence. Data were obtained from a randomized controlled trial of people living with HIV (N = 658) in China. Ordinal regression and logistic regression analyses were performed to examine associations between ART adherence, depression, and physical activity. A better ART adherence was associated with higher levels of physical activity (adjusted odds ratio [aOR] = 1.36, 95% confidence interval [CI] = 1.02-1.80) and lower levels of depression (aOR = 0.95, 95% CI = 0.92-0.99). Higher levels of physical activity were also associated with lower levels of depression (aOR = 0.50, 95% CI = 0.32-0.76). Sobel Z test indicated the mediating effect of depression between physical activity and ART adherence (Sobel Z = 1.96, p < .05). This study suggests the benefit of appropriate levels of physical activity to promote both psychological health and ART adherence in people living with HIV.
本研究旨在探讨身体活动、抑郁与抗逆转录病毒治疗（ART）依从性之间的关系。数据来自中国一项针对 HIV 感染者的随机对照试验（N=658）。采用有序回归和逻辑回归分析来检验 ART 依从性、抑郁和身体活动之间的关联。更高的 ART 依从性与更高水平的身体活动（调整后的优势比[aOR]=1.36，95%置信区间[CI]=1.02-1.80）和更低水平的抑郁（aOR=0.95，95%CI=0.92-0.99）相关。更高水平的身体活动也与更低水平的抑郁相关（aOR=0.50，95%CI=0.32-0.76）。Sobel Z 检验表明抑郁在身体活动和 ART 依从性之间具有中介作用（Sobel Z=1.96，p<0.05）。本研究表明，适当水平的身体活动有益于促进 HIV 感染者的心理健康和 ART 依从性。
