Patniyot Nicholas S, Patniyot Irene R
J Psychiatr Pract. 2019 Jan;25(1):58-62. doi: 10.1097/PRA.0000000000000352.
The case of a patient with a first presentation psychotic episode secondary to variant Creutzfeldt-Jakob Disease (vCJD) is presented. While psychiatric symptoms are considered a prominent feature of vCJD, they may precede characteristic neurological symptoms, which can delay diagnosis. The psychotic symptoms in this case differed in quality from typical psychotic presentations, which could have helped with earlier diagnosis. The patient's symptomatology suggested that errors in cognition and perception were largely contributing to his psychiatric symptoms. These errors appeared to be the result of prion destruction of relevant brain structures that may either be directly or secondarily involved in psychiatric disorders. The findings in this case can help elucidate how vCJD symptoms deviate from established guidelines for diagnosing primary psychiatric disorders.
本文介绍了一例因变异型克雅氏病（vCJD）首次出现精神病性发作的患者病例。虽然精神症状被认为是vCJD的一个突出特征，但它们可能先于特征性神经症状出现，这可能会延迟诊断。该病例中的精神病性症状在性质上与典型的精神病性表现不同，这可能有助于早期诊断。患者的症状表明，认知和感知错误在很大程度上导致了他的精神症状。这些错误似乎是朊病毒破坏相关脑结构的结果，这些脑结构可能直接或间接参与精神障碍。该病例的研究结果有助于阐明vCJD症状如何偏离原发性精神障碍的既定诊断指南。
