对俄罗斯联邦一所军事院校申请人中脑膜炎奈瑟菌鼻咽携带的观察性研究。

Observational study of nasopharyngeal carriage of Neisseria meningitidis in applicants to a military academy in the Russian Federation.

机构信息

Pediatric Research and Clinical Center for Infectious Diseases, Professor Popov Str. 9, Saint Petersburg, 197022, Russian Federation; North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, Kirochnaya Str. 41, 191015, Russian Federation.

S.M. Kirov Military Medical Academy, 194044, Academic Lebedev Str. 9, Saint Petersburg, 194044, Russian Federation.

出版信息

Int J Infect Dis. 2019 Apr;81:12-16. doi: 10.1016/j.ijid.2018.12.012. Epub 2019 Jan 8.

DOI:10.1016/j.ijid.2018.12.012

PMID:30634039

Abstract

OBJECTIVE

To determine the carriage and the serogroup distribution of Neisseria meningitidis in military academy applicants in the Russian Federation.

DESIGN

This was a prospective, observational study of adults aged >18years from a military academy; applicants who had samples taken on arrival (Day 1), and applicants who had samples taken after passing exams (Day 30) and 60days after arrival. N. meningitidis serogrouping was determined by slide agglutination tests of isolates and real-time PCR.

RESULTS

Samples were provided by 671 applicants on Day 1 and 261 applicants on Day 30, with 232 of these also providing samples on Day 60. N. meningitidis was detected in 16.2% of samples from Day 1, 7.7% of samples from Day 30 and 15.9% of samples from Day 60. Serogroup composition was most diverse at Day 1, with serogroups B and W dominant (40% [17/43 isolates] and 9% [4/43], respectively; 30% [13/43] ungroupable); by Day 60, there was a low diversity, with 58% (14/24 isolates) serogroup W.

CONCLUSIONS

While carriage of N. meningitidis in this study appeared stable, there was an increase in carriers of serogroup W in this population. Given recent increases in outbreaks attributed to serogroup W, further monitoring may be considered.

摘要

目的

确定俄罗斯军事学院申请人中脑膜炎奈瑟菌的携带情况和血清群分布。

设计

这是一项针对 18 岁以上军事学院成年人的前瞻性、观察性研究；申请人在到达时（第 1 天）和通过考试后（第 30 天）以及到达后 60 天（第 60 天）采集样本。通过分离物的玻片凝集试验和实时 PCR 确定脑膜炎奈瑟菌血清群。

结果

第 1 天有 671 名申请人提供了样本，第 30 天有 261 名申请人提供了样本，其中 232 名申请人还提供了第 60 天的样本。第 1 天样本中脑膜炎奈瑟菌的检出率为 16.2%，第 30 天样本中为 7.7%，第 60 天样本中为 15.9%。第 1 天血清群组成最多样化，血清群 B 和 W 占主导地位（分别为 40%[43 株中的 17 株]和 9%[43 株中的 4 株]；30%[43 株中的 13 株]无法分类）；到第 60 天，血清群多样性较低，血清群 W 占 58%（24 株中的 14 株）。