Ichihara K, Nabeshima T, Kameyama T
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan.
Eur J Pharmacol. 1988 Jul 14;151(3):435-42. doi: 10.1016/0014-2999(88)90540-7.
The main purpose of the present study was to examine the effect of dopamine blockers on memory processes by means of a one-trial passive avoidance (PA) task with ddY mice. Haloperidol (0.025-0.4 mg/kg i.p.) did not affect the PA response when it was given before the training or retention test. Sulpiride (10-80 mg/kg i.p.) had different effects, depending on the doses employed: A lower dose (20 mg/kg) of sulpiride, which is thought to block presynaptic receptors, impaired the PA response but higher doses (40 and 80 mg/kg i.p.) did not affect it when sulpiride was given before the training or retention test. SCH 23390 (0.025-0.1 mg/kg i.p.) impaired the PA response only when it was given before the training. These results suggest that blocking of postsynaptic D-2 receptors does not impair memory processes but blocking of presynaptic D-2 receptors impairs both acquisition and retrieval stages of memory processes following an increase in dopamine release. The involvement of D-1 receptors in memory processes involved in the PA response may be essentially different from that of D-2 receptors, since the blocking of D1 receptors impaired only memory acquisition.
本研究的主要目的是通过对ddY小鼠进行单次被动回避（PA）任务，来检测多巴胺受体阻滞剂对记忆过程的影响。当在训练或记忆保持测试前腹腔注射氟哌啶醇（0.025 - 0.4毫克/千克）时，对PA反应没有影响。舒必利（10 - 80毫克/千克腹腔注射）根据所用剂量产生不同影响：较低剂量（20毫克/千克）的舒必利被认为可阻断突触前受体，会损害PA反应，但在训练或记忆保持测试前腹腔注射较高剂量（40和80毫克/千克）时则不会产生影响。SCH 23390（0.025 - 0.1毫克/千克腹腔注射）仅在训练前给药时会损害PA反应。这些结果表明，阻断突触后D - 2受体不会损害记忆过程，但在多巴胺释放增加后，阻断突触前D - 2受体则会损害记忆过程的获取和检索阶段。PA反应所涉及的记忆过程中，D - 1受体的作用可能与D - 2受体的作用本质上不同，因为阻断D1受体仅损害记忆获取。
