Craxi A, Di Marco V, Volpes R, Palazzo U
Cattedra di Gastroenterologia, Clinica Medica R, University of Palermo.
Hepatogastroenterology. 1988 Dec;35(6):304-5.
Thirty-five patients with chronic viral hepatitis (B, D or non A, non B), treated with alpha interferon were evaluated by a highly sensitive enzyme immunoassay for the presence of alpha interferon neutralizing antibodies before and after three months of treatment. Although 4 subjects (11.4%) became immunized against alpha interferon, treatment with the drug was successful in inhibiting viral replication in 3 of them. We conclude that the appearance of anti alpha interferon antibodies does not affect the effectiveness of the drug, and is therefore not worth monitoring.
对35例慢性病毒性肝炎（乙型、丁型或非甲非乙型）患者使用α干扰素进行治疗，并在治疗三个月前后通过高灵敏度酶免疫测定法评估α干扰素中和抗体的存在情况。尽管有4名受试者（11.4%）产生了针对α干扰素的免疫反应，但其中3名患者使用该药物治疗成功抑制了病毒复制。我们得出结论，抗α干扰素抗体的出现并不影响药物的疗效，因此不值得监测。
