Department of Pathology, Dermatopathology Section, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
University of Santo Tomas Hospital Benavides Cancer Institute, Manila, Philippines.
J Clin Pathol. 2019 May;72(5):337-340. doi: 10.1136/jclinpath-2018-205504. Epub 2019 Jan 13.
Merkel cell carcinoma (MCC) is a rare primary cutaneous neuroendocrine carcinoma. The annual incidence of MCC is increasing in the USA. Timely diagnosis and proper staging of this tumour are crucial as MCC has high rates of regional recurrence and lymph node and distant metastasis. In this review, we outline the key differences between the tumor node metastasis (TNM) staging criteria for MCC in the seventh and eighth editions of the We also discuss histopathological parameters that are not included in the eighth edition of the manual but have been shown in other studies to predict a worse prognosis in patients with MCC. Correct assessment and reporting of these clinically relevant histopathological parameters is of utmost importance for practising pathologists as management differs according to the stage of the tumour. This review aims to increase awareness of all these parameters, and proper recognition would guide the treating clinicians towards the most appropriate treatment options that can be given to patients.
默克尔细胞癌（Merkel cell carcinoma，MCC）是一种罕见的原发性皮肤神经内分泌癌。在美国，MCC 的年发病率正在增加。及时诊断和正确分期对这种肿瘤至关重要，因为 MCC 具有较高的区域复发率以及淋巴结和远处转移率。在这篇综述中，我们概述了第七版和第八版 AJCC 肿瘤淋巴结转移（TNM）分期标准之间的关键差异。我们还讨论了第八版手册中未包含但在其他研究中已表明可预测 MCC 患者预后更差的组织病理学参数。对于临床病理学家来说，正确评估和报告这些临床相关的组织病理学参数非常重要，因为根据肿瘤的分期，治疗方法也不同。本综述旨在提高对所有这些参数的认识，正确识别将有助于治疗医生为患者选择最合适的治疗方案。
