Provazzi Paola Jocelan Scarin, Rossi Livia Maria Gonçalves, Carneiro Bruno Moreira, Miura Valeria Chamas, Rosa Plinio Cesar Rodrigues, de Carvalho Lucas Rodrigues, de Andrade Stephane Tereza Queiroz, Fachini Roberta Maria, Grotto Rejane Maria Tommasini, Silva Giovanni Faria, Valêncio Carlos Roberto, Neto Paulo Scarpelini, Cordeiro José Antonio, Nogueira Mauricio Lacerda, Rahal Paula
Department of Biology, São Paulo State University - UNESP, São José do Rio Preto, SP, 15054-000, Brazil.
Department of Hepatology, São José do Rio Preto Medical School, São José do Rio Preto, SP, 15090-000, Brazil.
Braz J Microbiol. 2019 Jan;50(1):147-155. doi: 10.1007/s42770-018-0008-3. Epub 2018 Dec 4.
Hepatitis C virus (HCV) infection is associated with chronic liver disease, resulting in cirrhosis and hepatocellular carcinoma. Approximately 20% of HCV infections are spontaneously resolved. Here, we assessed the hierarchical relevance of host factors contributing to viral clearance.
DNA samples from 40 resolved infections and 40 chronic HCV patients paired by age were analyzed. Bivariate analysis was performed to rank the importance of each contributing factor in spontaneous HCV clearance.
Interestingly, 63.6% of patients with resolved infections exhibited the protective genotype CC for SNP rs12979860. Additionally, 59.3% of patients with resolved infections displayed the protective genotype TT/TT for SNP ss469415590. Moreover, a ranking of clearance factors was estimated. In order of importance, the IL28B CC genotype (OR 0.197, 95% CI 0.072-0.541) followed by the INFL4 TT/TT genotype (OR 0.237, 95% CI 0.083-0.679), and female gender (OR 0.394, 95% CI 0.159-0.977) were the main predictors for clearance of HCV infection.
HCV clearance is multifactorial and the contributing factors display a hierarchical order. Identifying all elements playing role in HCV clearance is of the most importance for HCV-related disease management. Dissecting the relevance of each contributing factor will certainly improve our understanding of the pathogenesis of HCV infection.
丙型肝炎病毒（HCV）感染与慢性肝病相关，可导致肝硬化和肝细胞癌。约20%的HCV感染可自发清除。在此，我们评估了促成病毒清除的宿主因素的层次相关性。
分析了40例已清除感染患者和40例按年龄配对的慢性HCV患者的DNA样本。进行双变量分析以对每个促成因素在HCV自发清除中的重要性进行排名。
有趣的是，63.6%的已清除感染患者表现出针对单核苷酸多态性（SNP）rs12979860的保护性基因型CC。此外，59.3%的已清除感染患者表现出针对SNP ss469415590的保护性基因型TT/TT。此外，还估计了清除因素的排名。按重要性排序，IL28B CC基因型（比值比[OR]0.197，95%置信区间[CI]0.072 - 0.541）、其次是INFL4 TT/TT基因型（OR 0.237，95% CI 0.083 - 0.679）以及女性性别（OR 0.394，95% CI 0.159 - 0.977）是HCV感染清除的主要预测因素。
HCV清除是多因素的，且促成因素呈现层次顺序。确定在HCV清除中起作用的所有因素对于HCV相关疾病管理最为重要。剖析每个促成因素的相关性肯定会增进我们对HCV感染发病机制的理解。
