Carral-Menoyo Asier, Misol Alexander, Gómez-Redondo Marcos, Sotomayor Nuria, Lete Esther
Departamento de Química Orgánica II, Facultad de Ciencia y Tecnología , Universidad del País Vasco, Euskal Herriko Unibertsitatea UPV/EHU , Apdo. 644 , 48080 Bilbao , Spain.
J Org Chem. 2019 Feb 15;84(4):2048-2060. doi: 10.1021/acs.joc.8b03051. Epub 2019 Jan 25.
The intramolecular Pd(II)-catalyzed alkenylation of aryl homoallyl ethers constitutes a mild, versatile, and efficient procedure for the synthesis of highly and diversely substituted chromanes and 2 H-chromenes. The use of p-TsOH as an additive allows more efficient reactions that could be carried out a room temperature in most cases. The procedure has a wide scope, allowing the synthesis of alkylidenechromanes and 2 H-chromenes substituted at C-2 or C-3 of the chromene moiety, thus accessing relevant flavenes and isoflavenes, and even coumarins, in high yields (59 to 91%, 32 examples).
分子内钯（II）催化的芳基高烯丙基醚烯基化反应是一种温和、通用且高效的方法，用于合成高度多样化取代的色满和2H-色烯。使用对甲苯磺酸作为添加剂可使反应更高效，在大多数情况下可在室温下进行。该方法适用范围广泛，能够合成在色烯部分的C-2或C-3位被取代的亚烷基色满和2H-色烯，从而以高产率（59%至91%，32个实例）得到相关的黄酮和异黄酮，甚至香豆素。
