Department of Occupational Therapy and Graduate Institute of Behavioral Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Health and Social Sciences Cluster, Singapore Institute of Technology, Singapore.
Division of Cerebrovascular Diseases, Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan; Discharge Planning Service Center, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan; Department of Senior Citizen Service Management, Yuh-Ing Junior College, Kaohsiung, Taiwan.
Arch Phys Med Rehabil. 2019 May;100(5):821-827. doi: 10.1016/j.apmr.2018.12.020. Epub 2019 Jan 9.
To investigate the efficacy of a sequential combination of aerobic exercise and cognitive training on cognitive function and other health-related outcomes in stroke survivors with cognitive decline.
Intervention study and randomized controlled trial.
Hospital-based rehabilitation units.
Survivors of stroke with cognitive decline (N=30) were randomized to sequential combination training (SEQ) (n=15) or an active control (n=15) group.
The SEQ group received 30 minutes of aerobic exercise, followed by 30 minutes of computerized cognitive training. The control group received 30 minutes of nonaerobic physical exercise, followed by 30 minutes of unstructured mental activities.
The primary outcome measure was cognitive function. Secondary outcome measures included physical function, social participation, and quality of life.
Compared with the control group, the SEQ group had significantly improved Montreal Cognitive Assessment scores (P=.03) and Wechsler Memory Scale span scores (P=.012) after training. The endurance and mobility level measured by the 6-minute walk test (P=.25) was also enhanced in the SEQ group relative to the control group. However, the transfer of sequential training to social participation (Community Integration Questionnaire) and quality of life (EuroQoL questionnaire) was limited (P>.05 for both).
Aerobic exercise combined with computerized cognitive training has better effects on the cognitive functional status of survivors of stroke than an active control. The cognitive functional status of stroke survivors was better after participation in aerobic exercise combined with computerized training than after active control therapy, demonstrating the clinical significance of this combination therapy.
研究有氧运动和认知训练序贯结合对认知功能和其他健康相关结局的影响在认知功能下降的中风幸存者中。
干预研究和随机对照试验。
医院康复病房。
认知下降的中风幸存者（N=30）被随机分为序贯联合训练（SEQ）组（n=15）或主动对照组（n=15）。
SEQ 组接受 30 分钟的有氧运动，然后进行 30 分钟的计算机认知训练。对照组接受 30 分钟的非有氧运动，然后进行 30 分钟的非结构化心理活动。
主要观察指标为认知功能。次要观察指标包括身体功能、社会参与和生活质量。
与对照组相比，训练后 SEQ 组蒙特利尔认知评估评分（P=.03）和韦氏记忆量表跨度评分（P=.012）显著提高。SEQ 组的 6 分钟步行测试（P=.25）的耐力和移动水平也比对照组有所提高。然而，序贯训练对社会参与（社区融入问卷）和生活质量（EuroQoL 问卷）的转移作用有限（均 P>.05）。
有氧运动结合计算机认知训练对中风幸存者的认知功能状态的影响优于主动对照组。与主动对照组相比，参与有氧运动结合计算机训练后，中风幸存者的认知功能状态更好，表明这种联合治疗具有临床意义。
