Department of Surgery, University of Texas McGovern Medical School, Houston, TX; Center for Translational Injury Research, University of Texas McGovern Medical School, Houston, TX.
Department of Pediatrics, University of Texas McGovern Medical School, Houston, TX; Center for Clinical Research and Evidence Based Medicine, University of Texas McGovern Medical School, Houston, TX.
J Am Coll Surg. 2019 Mar;228(3):255-264. doi: 10.1016/j.jamcollsurg.2018.12.025. Epub 2019 Jan 9.
In an earlier study, we reported the successful reduction in the use of damage control laparotomy (DCL); however, no change in the relative frequencies of specific indications was observed. In this study, we aimed to use machine learning to help identify the changes in surgical decision making that occurred.
Adult patients undergoing emergent trauma laparotomy were included: pre-quality improvement (QI): January 1, 2011 to October 31, 2013 and post-QI: November 1, 2013 to June 30, 2016. Using 72 variables before or during emergent laparotomy, random forest algorithms predicting DCL before and after a QI intervention were created. The main end point of the algorithms was the strength of individual factor significance in predicting the use of DCL, calculated by determining the mean decrease in accuracy (MDA) in the model if that variable was removed.
In the pre-QI group, 24 of 72 factors significantly predicted DCL, the strongest being bowel resection (mean MDA 16) and operating room RBC transfusions (mean MDA 15). The remaining variables were spread along the continuum of care from injury to emergent laparotomy end. In the post-QI group, 12 of 72 factors significantly predicted DCL, the strongest being last operating room lactate (mean MDA 12) and operating room RBC transfusions (mean MDA 14). In addition to having 12 fewer significant factors predictive of DCL, the predictive factors in the post-QI group were mainly intraoperative factors.
A machine learning analysis provided novel insights into the changes in decision making achieved by a successful QI intervention and should be considered an adjunct to understanding successful pre- and post-intervention QI studies. The analysis suggested a shift toward using mostly intraoperative factors to determine the use of DCL.
在之前的一项研究中,我们报告了成功减少损伤控制性剖腹术(DCL)的使用;然而,并没有观察到特定适应症的相对频率发生变化。在这项研究中,我们旨在使用机器学习来帮助识别手术决策发生的变化。
纳入接受紧急创伤剖腹术的成年患者:质量改进(QI)前:2011 年 1 月 1 日至 2013 年 10 月 31 日和 QI 后:2013 年 11 月 1 日至 2016 年 6 月 30 日。在紧急剖腹术之前或期间使用 72 个变量,创建了预测 QI 干预前后 DCL 的随机森林算法。算法的主要终点是个体因素在预测 DCL 使用中的重要性,通过确定如果该变量被删除模型准确性下降的平均幅度(MDA)来计算。
在 QI 前组中,72 个因素中有 24 个因素显著预测了 DCL,最强的是肠切除术(平均 MDA 16)和手术室 RBC 输血(平均 MDA 15)。其余变量沿着从损伤到紧急剖腹术结束的护理连续体分布。在 QI 后组中,72 个因素中有 12 个因素显著预测了 DCL,最强的是最后手术室乳酸(平均 MDA 12)和手术室 RBC 输血(平均 MDA 14)。除了有 12 个预测 DCL 的显著因素减少外,QI 后组的预测因素主要是术中因素。
机器学习分析为成功的 QI 干预所实现的决策变化提供了新的见解,并且应该被视为理解成功的干预前和干预后 QI 研究的辅助手段。该分析表明,使用主要是术中因素来确定 DCL 的使用。