Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
East China Military Material Purchasing Bureau, Shanghai 200433, China.
Hum Immunol. 2019 Mar;80(3):191-194. doi: 10.1016/j.humimm.2019.01.001. Epub 2019 Jan 11.
CD3CD20 T cells are a population of CD3 T cells co-expressing CD20 that make up to ∼3-5% of the CD3 T-cell compartment in the peripheral blood of human beings. In healthy individuals, CD3CD20 T cells are heterogeneous for containing a lower proportion of CD4 cells, but produce higher levels of IL-17A and/or IFN-γ than those of CD3CD20 T cells. Recently, emerging studies have shown a pathogenic behavior of CD3CD20 T cells in autoimmune diseases and CD20 T-cell malignancies, and patients with the diseases may benefit from anti-CD20 immunotherapy to deplete these cells. However, CD3CD20 T cells may also play a protective role in ovarian cancer and HIV infection for their strong propensity to IFN-γ production. In this review, we will describe the current knowledge about CD3CD20 T-cell biology, and discuss their functional roles in autoimmune diseases as well as cancer and infectious diseases.
CD3CD20 T 细胞是一种共表达 CD20 的 CD3 T 细胞群体，占人类外周血 CD3 T 细胞群的 3-5%。在健康个体中，CD3CD20 T 细胞是异质性的，其中包含较低比例的 CD4 细胞，但产生的 IL-17A 和/或 IFN-γ 水平高于 CD3CD20 T 细胞。最近，新兴的研究表明 CD3CD20 T 细胞在自身免疫性疾病和 CD20 T 细胞恶性肿瘤中的致病性行为，并且这些疾病的患者可能受益于抗 CD20 免疫疗法来消耗这些细胞。然而，CD3CD20 T 细胞也可能在卵巢癌和 HIV 感染中发挥保护作用，因为它们具有强烈的 IFN-γ 产生倾向。在这篇综述中，我们将描述 CD3CD20 T 细胞生物学的现有知识，并讨论它们在自身免疫性疾病以及癌症和传染病中的功能作用。
