CD3CD20 T 细胞及其在人类疾病中的作用。
CD3CD20 T cells and their roles in human diseases.
机构信息
Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
East China Military Material Purchasing Bureau, Shanghai 200433, China.
出版信息
Hum Immunol. 2019 Mar;80(3):191-194. doi: 10.1016/j.humimm.2019.01.001. Epub 2019 Jan 11.
CD3CD20 T cells are a population of CD3 T cells co-expressing CD20 that make up to ∼3-5% of the CD3 T-cell compartment in the peripheral blood of human beings. In healthy individuals, CD3CD20 T cells are heterogeneous for containing a lower proportion of CD4 cells, but produce higher levels of IL-17A and/or IFN-γ than those of CD3CD20 T cells. Recently, emerging studies have shown a pathogenic behavior of CD3CD20 T cells in autoimmune diseases and CD20 T-cell malignancies, and patients with the diseases may benefit from anti-CD20 immunotherapy to deplete these cells. However, CD3CD20 T cells may also play a protective role in ovarian cancer and HIV infection for their strong propensity to IFN-γ production. In this review, we will describe the current knowledge about CD3CD20 T-cell biology, and discuss their functional roles in autoimmune diseases as well as cancer and infectious diseases.
CD3CD20 T 细胞是一种共表达 CD20 的 CD3 T 细胞群体，占人类外周血 CD3 T 细胞群的 3-5%。在健康个体中，CD3CD20 T 细胞是异质性的，其中包含较低比例的 CD4 细胞，但产生的 IL-17A 和/或 IFN-γ 水平高于 CD3CD20 T 细胞。最近，新兴的研究表明 CD3CD20 T 细胞在自身免疫性疾病和 CD20 T 细胞恶性肿瘤中的致病性行为，并且这些疾病的患者可能受益于抗 CD20 免疫疗法来消耗这些细胞。然而，CD3CD20 T 细胞也可能在卵巢癌和 HIV 感染中发挥保护作用，因为它们具有强烈的 IFN-γ 产生倾向。在这篇综述中，我们将描述 CD3CD20 T 细胞生物学的现有知识，并讨论它们在自身免疫性疾病以及癌症和传染病中的功能作用。
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