Sección de Neurobiología de las Sensaciones Orales, Laboratorio de Investigación Odontológica, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México Sección de Neurobiología de las sensaciones orales, Facultad de Estudios Superiores Iztacala, UNAM, Av. de los Barrios 1, Los reyes Ixtacala, Hab Los Reyes Ixtacala Barrio de los Árboles/Barrio de los Héroes, 54090 Tlalnepantla, Mexico.
Sección de Neurobiología de las Sensaciones Orales, Laboratorio de Investigación Odontológica, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México Sección de Neurobiología de las sensaciones orales, Facultad de Estudios Superiores Iztacala, UNAM, Av. de los Barrios 1, Los reyes Ixtacala, Hab Los Reyes Ixtacala Barrio de los Árboles/Barrio de los Héroes, 54090 Tlalnepantla, Mexico.
Arch Oral Biol. 2019 Mar;99:66-72. doi: 10.1016/j.archoralbio.2019.01.004. Epub 2019 Jan 7.
Dental treatment and orofacial surgeries may induce chronic neuropathic orofacial pain (CNOP). This kind of pain affects adaptability to environmental changes in both model animals and humans. Part of the adaptation process depends on the ability to distinguish between familiar and novel stimuli. CNOP induces novelty seeking behaviour as a deficit in environmental adaptation. Alternatively, novelty seeking is a sign for susceptibility to the development of substance abuse. Evidence shows that CNOP leads to alcoholism in animal models. The behavioural relationship between CNOP, novelty seeking behaviour and substance abuse is unknown. In this article, we investigate if CNOP produces an increase in novelty seeking and leads to increasing ethanol intake.
Firstly, we used mental nerve injury as a neuropathic orofacial pain model to evaluate both thermal and mechanical allodynia. We used the novel recognition task to determine novelty seeking behaviour and the drink in darkness protocol to assess ethanol intake.
Our results show that mental nerve constriction increases novelty seeking behaviour (p = 0.01) and correlates with ethanol binge consumption (r = 0.68, p = 0.0008).
The present study demonstrates, for the first time, that trigeminal nerve injury, which induces CNOP, is enough to provide novelty seeking behaviour and lead to increasing ethanol intake. The increase of novelty seeking behaviour can serve as a predictor of risk of developing substance abuse. The treatment of CNOP involves a high risk of producing addiction. The level of novelty seeking evaluation in patients with neuropathic pain before treatment is critical.
牙科治疗和口腔颌面手术可能会引起慢性神经性口腔疼痛（CNOP）。这种疼痛会影响模型动物和人类对环境变化的适应能力。适应过程的一部分取决于区分熟悉和新颖刺激的能力。CNOP 会引起对环境适应的新奇寻求行为缺陷。或者，新奇寻求是对物质滥用发展易感性的标志。有证据表明，CNOP 会导致动物模型中的酒精中毒。CNOP、新奇寻求行为和物质滥用之间的行为关系尚不清楚。在本文中，我们研究了 CNOP 是否会增加新奇寻求行为并导致乙醇摄入量增加。
首先，我们使用面神经损伤作为神经性口腔疼痛模型来评估热和机械性痛觉过敏。我们使用新颖识别任务来确定新奇寻求行为，并用黑暗中的饮酒协议来评估乙醇摄入量。
我们的结果表明，面神经缩窄会增加新奇寻求行为（p=0.01），并与乙醇 binge 消费相关（r=0.68，p=0.0008）。
本研究首次表明，三叉神经损伤诱导 CNOP 足以提供新奇寻求行为并导致乙醇摄入量增加。新奇寻求行为的增加可以作为产生物质滥用风险的预测指标。CNOP 的治疗会产生很高的成瘾风险。治疗前神经性疼痛患者的新奇寻求行为评估水平至关重要。
