氯化汞和汞撒利对调节细胞内钙及递质释放机制的影响。

The effects of HGCl2 and mersalyl on mechanisms regulating intracellular calcium and transmitter release.

作者信息

Binah O, Meiri U, Rahamimoff H

出版信息

Eur J Pharmacol. 1978 Oct 15;51(4):453-7. doi: 10.1016/0014-2999(78)90438-7.

Abstract

HgCl2 and mersalyl increased and later decreased both the spontaneous and evoked transmitter liberation at the frog neuromuscular junction. Lower concentration of HgCl2 exhibited only an inhibitory effect on transmitter release. These mercurials inhibited calcium transport of mitochondria and synaptosomal vesicles. Lower concentrations of HgCl2 showed a stimulatory effect on mitochondrial calcium uptake. It is suggested that the effect of mercurials on transmitter release is mediated via changes of the intracellular calcium ion concentration.

摘要

氯化汞和汞撒利先是增加随后又减少了青蛙神经肌肉接头处的自发递质释放和诱发递质释放。较低浓度的氯化汞仅对递质释放表现出抑制作用。这些汞剂抑制了线粒体和突触体小泡的钙转运。较低浓度的氯化汞对线粒体钙摄取表现出刺激作用。有人提出，汞剂对递质释放的作用是通过细胞内钙离子浓度的变化介导的。