National Hospital Organization Hizen Psychiatric Center, 160 Mitsu Yoshinogari, Kanzaki, Saga 842-0192, Japan.
Department of Psychiatry, Faculty of Medicine, Saga University, Saga, Japan.
Psychiatry Res. 2019 Mar;273:67-74. doi: 10.1016/j.psychres.2018.12.139. Epub 2018 Dec 27.
There were few reports of oxytocin (OXT) concentrations of autism spectrum disorder (ASD) patients with severe intellectual disabilities. We measured serum OXT concentrations in 79 hospitalized patients with severe intellectual disabilities (16-60 years old, 50 males and 29 females, 54 ASD patients) and investigated the associations between serum OXT concentration, symptom scores, sex differences, and autism spectrum disorder. There were no significant effects of diagnosis, severity of intellectual disabilities, and total score of the Japanese version of the Aberrant Behavior Checklist (ABC-J), the Childhood Autism Rating Scale-Tokyo Version (CARS-TV), and the Japanese version of the Repetitive Behavior Scale-Revised (RBS-R). However, there were sex differences in the correlations between OXT concentrations and subscale scores in the ASD group. The male ASD group (n = 39) showed negative correlations between RBS-R Self-injurious and Sameness subscale scores and serum OXT concentrations. In the female ASD group(n = 15), CARS-TV Nonverbal communication subscale scores and RBS-R Compulsive subscale scores were seen to positively correlate with serum OXT concentrations. These findings suggest that OXT functions differ in males and females with severe intellectual disabilities and that OXT partly affects autism and related to some of the repetitive behaviors and nonverbal communication, in ASD patients with severe intellectual disabilities.
目前鲜有关于伴有严重智力障碍的自闭症谱系障碍（ASD）患者的催产素（OXT）浓度的报道。我们测量了 79 名患有严重智力障碍（16-60 岁，男性 50 名，女性 29 名，54 名 ASD 患者）的住院患者的血清 OXT 浓度，并探讨了血清 OXT 浓度与症状评分、性别差异和自闭症谱系障碍之间的关系。诊断、智力障碍严重程度以及日本版异常行为检查表（ABC-J）、东京版儿童自闭症评定量表（CARS-TV）和日本版重复行为量表修订版（RBS-R）总分均无显著影响。然而，在 ASD 组中，OXT 浓度与亚量表评分之间的相关性存在性别差异。男性 ASD 组（n=39）的 RBS-R 自我伤害和同一性亚量表评分与血清 OXT 浓度呈负相关。在女性 ASD 组（n=15）中，CARS-TV 非言语交流亚量表评分和 RBS-R 强迫亚量表评分与血清 OXT 浓度呈正相关。这些发现表明，在伴有严重智力障碍的男性和女性中，OXT 的功能存在差异，OXT 部分影响自闭症，与一些重复行为和非言语交流有关，在伴有严重智力障碍的 ASD 患者中。
