学龄前儿童喘息和哮喘的表型
Phenotypes of wheezing and asthma in preschool children.
作者信息
Kwong Christina G, Bacharier Leonard B
机构信息
Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA.
出版信息
Curr Opin Allergy Clin Immunol. 2019 Apr;19(2):148-153. doi: 10.1097/ACI.0000000000000516.
Abstract
PURPOSE OF REVIEW
The purpose of this review is to provide an overview of the identified phenotypes of preschool wheezing.
RECENT FINDINGS
Early life wheezing patterns have been described in multiple populations, with several commonalities found between cohorts. Early life environmental exposures have been found to be differentially associated with preschool wheezing phenotypes and their future trajectories. These include allergen and microbe exposure, environmental tobacco smoke exposure, and maternal stress and depression. Elevated IgE in early life may also influence future asthma risk.
SUMMARY
Preschool wheezing phenotypes are heterogeneous and complex, with trajectories that are related to factors including environmental exposures. More research is needed to characterize these relationships, hopefully leading to targeted prevention strategies.
摘要
综述目的
本综述旨在概述已确定的学龄前喘息的表型。
最新发现
在多个人群中描述了生命早期的喘息模式，不同队列之间发现了一些共性。已发现生命早期的环境暴露与学龄前喘息表型及其未来发展轨迹存在差异关联。这些暴露包括过敏原和微生物暴露、环境烟草烟雾暴露以及母亲的压力和抑郁。生命早期IgE升高也可能影响未来患哮喘的风险。
总结
学龄前喘息表型具有异质性和复杂性，其发展轨迹与包括环境暴露在内的多种因素相关。需要更多研究来描述这些关系，有望由此制定有针对性的预防策略。
相似文献
1
Phenotypes of wheezing and asthma in preschool children.学龄前儿童喘息和哮喘的表型
Curr Opin Allergy Clin Immunol. 2019 Apr;19(2):148-153. doi: 10.1097/ACI.0000000000000516.
2
Are influences during pregnancy associated with wheezing phenotypes during the first decade of life?孕期受到的影响是否与生命最初十年的喘息表型有关？
Acta Paediatr. 2005 May;94(5):553-8. doi: 10.1111/j.1651-2227.2005.tb01938.x.
3
From preschool wheezing to asthma: Environmental determinants.从幼儿喘息到哮喘：环境决定因素。
Pediatr Allergy Immunol. 2023 Nov;34(11):e14049. doi: 10.1111/pai.14049.
4
Epidemiology of asthma and recurrent wheeze in childhood.儿童哮喘与复发性喘息的流行病学
Clin Rev Allergy Immunol. 2002 Feb;22(1):33-44. doi: 10.1007/s12016-002-0004-z.
5
Novel severe wheezy young children phenotypes: boys atopic multiple-trigger and girls nonatopic uncontrolled wheeze.新型严重喘息婴幼儿表型：男孩特应性多触发和女孩非特应性未控制喘息。
J Allergy Clin Immunol. 2012 Jul;130(1):103-10.e8. doi: 10.1016/j.jaci.2012.02.041. Epub 2012 Apr 13.
6
Presence of asthma risk factors and environmental exposures related to upper respiratory infection-triggered wheezing in middle school-age children.中学年龄儿童中与上呼吸道感染引发的喘息相关的哮喘风险因素和环境暴露情况。
Environ Health Perspect. 2003 Apr;111(4):657-62. doi: 10.1289/ehp.5824.
7
Asthma and wheezing in the first six years of life. The Group Health Medical Associates.生命最初六年中的哮喘与喘息。集团健康医疗协会。
N Engl J Med. 1995 Jan 19;332(3):133-8. doi: 10.1056/NEJM199501193320301.
8
Early-life exposure to household chemicals and wheezing in children.儿童期早期暴露于家庭化学品与喘息
Sci Total Environ. 2019 May 1;663:418-425. doi: 10.1016/j.scitotenv.2019.01.254. Epub 2019 Jan 25.
9
Asthma phenotypes in childhood: lessons from an epidemiological approach.儿童哮喘的表型：流行病学方法带来的启示
Paediatr Respir Rev. 2004 Jun;5(2):155-61. doi: 10.1016/j.prrv.2004.01.007.
10
Risk factors and characteristics of respiratory and allergic phenotypes in early childhood.婴幼儿期呼吸道和过敏表型的危险因素及特征。
J Allergy Clin Immunol. 2012 Aug;130(2):389-96.e4. doi: 10.1016/j.jaci.2012.05.054.
引用本文的文献
1
Internal migration and its association with childhood asthma in Ecuador: a cross-sectional study.厄瓜多尔的国内移民及其与儿童哮喘的关联：一项横断面研究。
Colomb Med (Cali). 2024 Jun 30;55(2):e2035929. doi: 10.25100/cm.v55i2.5929. eCollection 2024 Apr-Jun.
2
A Review of the Latest Guidelines for Diagnosing and Managing Asthma in Children in the United States and Canada.美国和加拿大儿童哮喘诊断与管理最新指南综述
Cureus. 2024 Aug 29;16(8):e68135. doi: 10.7759/cureus.68135. eCollection 2024 Aug.
3
Environmental exposures associated with early childhood recurrent wheezing in the mother and child in the environment birth cohort: a time-to-event study.与母婴环境出生队列中幼儿反复喘息相关的环境暴露：一项事件时间研究。
Thorax. 2024 Sep 18;79(10):953-960. doi: 10.1136/thorax-2023-221150.
4
Clinical features and later prognosis of replicable early-life wheeze clusters from two birth cohorts 12 years apart.相隔 12 年的两个出生队列中可复制的早发性喘息簇的临床特征和后期预后。
Pediatr Allergy Immunol. 2023 Jul;34(7):e13999. doi: 10.1111/pai.13999.
5
Network analyses of upper and lower airway transcriptomes identify shared mechanisms among children with recurrent wheezing and school-age asthma.上下呼吸道转录组的网络分析鉴定了反复喘息和学龄期哮喘儿童之间的共同机制。
Front Immunol. 2023 Jan 27;14:1087551. doi: 10.3389/fimmu.2023.1087551. eCollection 2023.
6
Identification of potential key genes for immune infiltration in childhood asthma by data mining and biological validation.通过数据挖掘和生物学验证鉴定儿童哮喘免疫浸润的潜在关键基因
Front Genet. 2022 Sep 2;13:957030. doi: 10.3389/fgene.2022.957030. eCollection 2022.
7
Diagnosis and management of asthma in infants and preschoolers.婴幼儿哮喘的诊断与管理
Clin Exp Pediatr. 2022 Dec;65(12):574-584. doi: 10.3345/cep.2021.01746. Epub 2022 Apr 19.
8
Management of asthma in childhood: study protocol of a systematic evidence update by the Paediatric Asthma in Real Life (PeARL) Think Tank.儿童哮喘管理：儿科真实生活中的哮喘（PeARL）智库进行系统证据更新的研究方案。
BMJ Open. 2021 Jul 2;11(7):e048338. doi: 10.1136/bmjopen-2020-048338.
9
[Predictors of hospitalization plus airway support among infants with recurrent wheezing in the emergency department].[急诊科反复喘息婴儿住院及气道支持的预测因素]
Zhongguo Dang Dai Er Ke Za Zhi. 2021 May;23(5):438-444. doi: 10.7499/j.issn.1008-8830.2011106.
10
Maternal Prenatal Hair Cortisol Is Associated with Child Wheeze among Mothers and Infants with Tobacco Smoke Exposure and Who Face High Socioeconomic Adversity.在暴露于烟草烟雾且面临高社会经济逆境的母婴中，母亲产前头发中的皮质醇与儿童喘息有关。
Int J Environ Res Public Health. 2021 Mar 9;18(5):2764. doi: 10.3390/ijerph18052764.
本文引用的文献
1
Longitudinal Phenotypes of Respiratory Health in a High-Risk Urban Birth Cohort.高危城市出生队列中呼吸健康的纵向表型。
Am J Respir Crit Care Med. 2019 Jan 1;199(1):71-82. doi: 10.1164/rccm.201801-0190OC.
2
U-BIOPRED: evaluation of the value of a public-private partnership to industry.U-BIOPRED：评估公私合作伙伴关系对产业的价值。
Drug Discov Today. 2018 Sep;23(9):1622-1634. doi: 10.1016/j.drudis.2018.06.015. Epub 2018 Jun 21.
3
Wheeze trajectories are modifiable through early-life intervention and predict asthma in adolescence.喘息轨迹可以通过生命早期干预来改变，并可预测青少年时期的哮喘。
Pediatr Allergy Immunol. 2018 Sep;29(6):612-621. doi: 10.1111/pai.12922. Epub 2018 Jun 19.
4
Wheezing phenotypes and risk factors in early life: The ELFE cohort.婴幼儿喘息表型及相关危险因素：ELFE 队列研究。
PLoS One. 2018 Apr 27;13(4):e0196711. doi: 10.1371/journal.pone.0196711. eCollection 2018.
5
Mechanisms of the Development of Allergy (MeDALL): Introducing novel concepts in allergy phenotypes.过敏发生机制研究（MeDALL）：揭示过敏表型的新概念。
J Allergy Clin Immunol. 2017 Feb;139(2):388-399. doi: 10.1016/j.jaci.2016.12.940.
6
Latent class analysis reveals clinically relevant atopy phenotypes in 2 birth cohorts.潜类分析揭示了 2 个出生队列中具有临床意义的特应性表型。
J Allergy Clin Immunol. 2017 Jun;139(6):1935-1945.e12. doi: 10.1016/j.jaci.2016.08.046. Epub 2016 Oct 19.
7
Childhood asthma prediction models: a systematic review.儿童哮喘预测模型：系统评价。
Lancet Respir Med. 2015 Dec;3(12):973-84. doi: 10.1016/S2213-2600(15)00428-2. Epub 2015 Nov 18.
8
The Early Development of Wheeze. Environmental Determinants and Genetic Susceptibility at 17q21.喘息的早期发展。17q21 的环境决定因素和遗传易感性。
Am J Respir Crit Care Med. 2016 Apr 15;193(8):889-97. doi: 10.1164/rccm.201507-1493OC.
9
Childhood wheezing, asthma, allergy, atopy, and lung function: different socioeconomic patterns for different phenotypes.儿童喘息、哮喘、过敏、特应性和肺功能：不同表型的不同社会经济模式。
Am J Epidemiol. 2015 Nov 1;182(9):763-74. doi: 10.1093/aje/kwv045. Epub 2015 Oct 6.
10
Inner city asthma.城市中心区哮喘
Immunol Allergy Clin North Am. 2015 Feb;35(1):101-14. doi: 10.1016/j.iac.2014.09.006. Epub 2014 Oct 18.
Zotero 插件