Simonett Joseph M, Igelman Austin, Taylor Stanford C, Campbell J Peter, Hwang Thomas S, Lin Phoebe, Lauer Andreas K, Flaxel Christina J
Ophthalmic Surg Lasers Imaging Retina. 2019 Jan 1;50(1):33-38. doi: 10.3928/23258160-20181212-05.
To report on the microbiology, management, and visual outcomes of intravitreal injection (IVI)-associated, culture-proven endophthalmitis.
All patients seen at a tertiary referral center with culture-proven endophthalmitis associated with an IVI between June 2007 and July 2017 were included in this retrospective analysis.
Thirty-five patients with culture-positive endophthalmitis following IVI were identified. All gram-positive organisms (34 of 35) were susceptible to vancomycin. Cases due to pathogens associated with oral or respiratory flora were common (31.4%, n = 11), presented earlier (2.0 days vs. 4.6 days, P < .001), were more likely to undergo pars plana vitrectomy (81.8% vs. 25.0%, P = .002) and had worse visual acuity outcomes.
IVI-associated endophthalmitis pathogens and anti-microbial susceptibilities in the Pacific Northwest are similar to those reported from other geographic locations. Bacteria associated with the oral and respiratory flora are common isolates that result in a more aggressive course and worse visual outcomes. [Ophthalmic Surg Lasers Imaging Retina. 2019;50:33-38.].
报告玻璃体内注射（IVI）相关的、经培养证实的眼内炎的微生物学、治疗及视力预后情况。
本回顾性分析纳入了2007年6月至2017年7月间在一家三级转诊中心就诊的、经培养证实与玻璃体内注射相关的眼内炎患者。
共确定了35例玻璃体内注射后培养阳性的眼内炎患者。所有革兰氏阳性菌（35例中的34例）对万古霉素敏感。由与口腔或呼吸道菌群相关的病原体引起的病例很常见（31.4%，n = 11），发病更早（2.0天对4.6天，P < .001），更有可能接受玻璃体切割术（81.8%对25.0%，P = .002），且视力预后更差。
太平洋西北地区玻璃体内注射相关眼内炎的病原体及抗菌药敏情况与其他地理位置报告的情况相似。与口腔和呼吸道菌群相关的细菌是常见的分离菌，会导致更具侵袭性的病程和更差的视力预后。[《眼科手术、激光与视网膜成像》。2019；50：33 - 38。]
