Wang Lin-Gan, Zhai Qiong-Xiang, Tang Zhi-Hong, Zhang Yu-Xin, Guo Yu-Xiong, Chen Zhi-Hong, Wang Chun, Zhuo Mu-Qing, Zeng Xiao-Lu, Zhang Jing-Wen
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2016 Aug;36(8):912-915.
Objective To observe changes of serum neuron specific enolase (NSE) level in children patients with epilepsy by additional use of ilepcimide (piperine derivative). Methods Totally 107 epilepsy children patients were assigned to the test group (77 cases) and the control group (30 cases) ac- cording to random digit table. Children patients in the control group received anti-epileptic Western drugs only. Those in the test group additionally took ilepcimide, 5 mg/kg per day as initial dose, taken in two times. The dose was gradually added to those without control of epilepsy attack. Added dose within a week should not exceed 10 mg/kg per day. The therapeutic course for all was one year. Electoencephalo- gram (EEG) was performed before treatment, half a year after treatment, and one year after treatment, respectively. Serum NSE level was detected using electrochemiluminescence. Efficacy was assessed after 1-year treatment. Results The total effective rate was 65. 0% (50177) in the test group, with statistical difference as compared with that in the control group [30. 0% (9/30), P <0. 01 ]. Compared with before treatment, serum NES-level obviously decreased in the test group after 0. 5-year treatment and 1- year treatment respectively (P <0. 05, P <0. 01). Besides, serum NES level was lower after 1-year treatment than after 0. 5-year treatment (P <0. 05, P <0. 01). There was no statistical difference in serum NES level between the test group and the control group at each time point (P >0. 05). Results of EEG were obviously superior in the test group (3 with normal range EEG, 5 critically abnormal EEG, 69 abnormal EEG) to the control group (2 with normal range EEG and 75 abnormal EEG) after 1-year treatment, with statistical difference (Z= -2. 33, P <0. 05). There was no statistical difference in EEG results of the control group between before treatment (all abnormal EEG) and after 1-year treatment (3 critically abnormal EEG and 27 abnormal EEG) (Z = -1. 732, P > 0. 05). Conclusion Adding ilepcimide (piperine derivative) for epilepsy children patients could lower serum NSE level and the frequency of seizures, and improve results of EEG.
目的 观察加用胡椒碱衍生物异胡椒酰胺对癫痫患儿血清神经元特异性烯醇化酶（NSE）水平的影响。方法 将107例癫痫患儿按随机数字表法分为试验组（77例）和对照组（30例）。对照组患儿仅接受抗癫痫西药治疗。试验组患儿在对照组治疗基础上加用异胡椒酰胺，初始剂量为5mg/kg，每日2次，若癫痫发作未得到控制则逐渐增加剂量，1周内增加剂量不超过10mg/kg。两组疗程均为1年。分别于治疗前、治疗半年后、治疗1年后进行脑电图（EEG）检查，采用电化学发光法检测血清NSE水平，治疗1年后评估疗效。结果 试验组总有效率为65.0%（50/77），与对照组[30.0%（9/30）]比较，差异有统计学意义（P<0.01）。试验组治疗半年后、治疗1年后血清NSE水平分别较治疗前明显降低（P<0.05，P<0.01），且治疗1年后血清NSE水平低于治疗半年后（P<0.05，P<0.01）。试验组与对照组各时间点血清NSE水平比较，差异无统计学意义（P>0.05）。治疗1年后试验组脑电图结果（脑电图正常范围3例，重度异常5例，异常69例）明显优于对照组（脑电图正常范围2例，异常75例），差异有统计学意义（Z=-2.33，P<0.05）。对照组治疗前（均为脑电图异常）与治疗1年后（重度异常3例，异常27例）脑电图结果比较，差异无统计学意义（Z=-1.732，P>0.05）。结论 加用胡椒碱衍生物异胡椒酰胺治疗癫痫患儿可降低血清NSE水平，减少癫痫发作频率，改善脑电图结果。
