Kakoulidis Ioannis, Ilias Ioannis, Linardi Anastasia, Milionis Charalampos, Michou Aikaterini, Koukkou Eftychia
Department of Endocrinology, Diabetes and Metabolism, Elena Venizelou General and Maternity Hospital, Athens, Greece.
Department of Endocrinology, Diabetes and Metabolism, Elena Venizelou General and Maternity Hospital, Athens, Greece.
Diabetes Metab Syndr. 2019 Jan-Feb;13(1):214-215. doi: 10.1016/j.dsx.2018.08.001. Epub 2018 Aug 2.
Betamethasone's effect on glucose homeostasis in the presence of gestational diabetes has not been adequately investigated.
MATERIALS-METHODS: We assessed the glycemic profile of 99 women with gestational diabetes (52 on insulin, 47 on medical nutrition therapy) who were given betamethasone during hospitalization for at risk pregnancies.
In insulin-treated women the increase in total daily insulin dose significantly linked to betamethasone dose (p = 0.014). In women on diet, the need for insulin was positively related to betamethasone dose, age and gestational age >34th week (all p < 0.05).
Parsimonious betamethasone use might still be beneficial with a milder effect on glycemia.
倍他米松对妊娠期糖尿病患者葡萄糖稳态的影响尚未得到充分研究。
我们评估了99例妊娠期糖尿病女性（52例接受胰岛素治疗，47例接受医学营养治疗）在因高危妊娠住院期间接受倍他米松治疗后的血糖情况。
在接受胰岛素治疗的女性中，每日胰岛素总剂量的增加与倍他米松剂量显著相关（p = 0.014）。在接受饮食治疗的女性中，胰岛素需求与倍他米松剂量、年龄以及孕周>34周呈正相关（所有p < 0.05）。
谨慎使用倍他米松可能仍然有益，对血糖的影响较小。
