Schauer A, Rothe H, Balzer I, Fiebig I, Rauschecker H
Zentrum Pathologie der Universität Göttingen.
Rontgenblatter. 1988 Aug;41(8):340-4.
Immunohistochemical methods assure the discrimination between neoplastic and reactive Lesions. Epithelial and mesenchymal neoplastic processes can absolutely be distinguished by antibodies directed to intermediate filaments. Growth activity of breast cancer can be evaluated using antibodies against epidermal growth factor receptor and Ki-67 proliferative protein. With antibodies directed to nuclear steroid receptor proteins semiquantitative determinations (immunoreactive score = IRS) and evaluation of genotypic heterogeneity are possible and may be helpful for therapeutic decisions.
免疫组织化学方法可确保区分肿瘤性病变和反应性病变。通过针对中间丝的抗体，上皮性和间叶性肿瘤性病变绝对可以区分开来。使用针对表皮生长因子受体和Ki-67增殖蛋白的抗体，可以评估乳腺癌的生长活性。利用针对核类固醇受体蛋白的抗体，可以进行半定量测定（免疫反应评分=IRS）并评估基因型异质性，这可能有助于治疗决策。
