Industry-University Cooperation Foundation, Hanyang University, Seoul, Republic of Korea.
Industry-University Cooperation Foundation, Hanyang University, Seoul, Republic of Korea; Department of Biomedical Systems Informatics, College of Medicine, Yonsei University, Seoul, Republic of Korea.
Am J Prev Med. 2019 Mar;56(3):393-403. doi: 10.1016/j.amepre.2018.10.017. Epub 2019 Jan 12.
Family history of cancer and modifiable risk factors are each associated with cancer development, but no studies have assessed their association with each other by sex. This study aimed to examine modifiable risk factors in individuals with a family history of cancer compared with those without a family history of cancer, according to sex.
This study recruited 166,810 participants aged 40-79 years from Korea's Health Examinee Study cohort between 2004 and 2014. Results were calculated as AORs and 95% CIs to determine the relationship between family history of cancer in first-degree relatives and modifiable risk factors. Data analyses were performed in 2018.
The prevalence of modifiable cancer risk factors, including current smoking, drinking alcohol, physical inactivity, obesity, and abdominal obesity, were different according to the presence of a family history of cancer, cancer type of such a family history, and sex. Male participants with a family history of cancer were less likely to be current smokers or obese (AOR=0.95, 95% CI=0.91, 0.99 and AOR=0.95, 95% CI=0.92, 0.99, respectively) than those without a family history of cancer, whereas female participants with a family history of cancer were more likely to be current smokers but less likely to be physically inactive (AOR=1.13, 95% CI=1.03, 1.23 and AOR=0.96, 95% CI=0.93, 0.98, respectively) than those without a family history of cancer.
This study's findings suggest that, in general, males with a family history of cancer show better health behaviors, whereas females with a family history of cancer demonstrate worse health behaviors.
癌症家族史和可改变的风险因素都与癌症的发生有关，但没有研究按性别评估它们之间的相互关系。本研究旨在按性别评估有癌症家族史的个体与无癌症家族史的个体之间的可改变风险因素。
本研究于 2004 年至 2014 年期间从韩国健康检查研究队列中招募了 166810 名年龄在 40-79 岁的参与者。结果以比值比（AOR）和 95%置信区间（CI）表示，以确定一级亲属的癌症家族史与可改变的风险因素之间的关系。数据分析于 2018 年进行。
根据癌症家族史的存在、这种家族史的癌症类型和性别，可改变的癌症风险因素（包括当前吸烟、饮酒、身体活动不足、肥胖和腹部肥胖）的流行率不同。有癌症家族史的男性参与者比没有癌症家族史的参与者更不可能是当前吸烟者或肥胖者（AOR=0.95，95%CI=0.91，0.99 和 AOR=0.95，95%CI=0.92，0.99），而有癌症家族史的女性参与者更可能是当前吸烟者，但不太可能是身体活动不足（AOR=1.13，95%CI=1.03，1.23 和 AOR=0.96，95%CI=0.93，0.98）。
本研究结果表明，一般来说，有癌症家族史的男性表现出更好的健康行为，而有癌症家族史的女性表现出更差的健康行为。
