焦虑和儿茶酚-O-甲基转移酶 (COMT) 和 5-羟色胺转运体基因 (5HTT) 的遗传多态性与良性游走性舌炎有关。

Anxiety and genetic polymorphisms in catechol-O-methyltransferase (COMT) and serotonin transportation gene (5HTT) are associated with benign migratory glossitis.

机构信息

Professor in School of Health and Biological Sciences, Positivo University, Curitiba, Brazil; Professor in Department of Stomatology, Federal University of Parana, Curitiba, Brazil.

Student in Dentistry, Positivo University, Curitiba, Brazil.

出版信息

Oral Surg Oral Med Oral Pathol Oral Radiol. 2019 Mar;127(3):218-224. doi: 10.1016/j.oooo.2018.10.011. Epub 2018 Nov 10.

DOI:10.1016/j.oooo.2018.10.011

PMID:30642702

Abstract

OBJECTIVE

The aim of this case-control study was to investigate whether benign migratory glossitis (BMG) is associated with catechol-O-methyltransferase (COMT) and serotonin transportation gene (5HTT) polymorphisms and anxiety.

STUDY DESIGN

The study comprised 43 patients with BMG and 114 patients without a history of BMG. We used the Hamilton Anxiety (HAM-A) rating scale to assess each individual's anxiety. We collected DNA from buccal cells and analyzed polymorphisms of COMT and 5HTT. We conducted statistical evaluations by using SPSS software (SPSS Inc., Chicago, IL) and STATA (StataCorp, College Station, TX). Alpha value was set at 0.05.

RESULTS

Overall anxiety level was significantly higher in the case group than in the control group (P < .001). In adjusted multiple logistic regression, the COMT markers were not associated with BMG. Individuals with the CC genotype, in rs3813034 of 5HTT, presented an odds ratio (OR) of 2.85 (95% confidence interval [CI] 1.03-7.82; P = .042). Individuals with the TT genotype, in the rs1042173 of 5HTT, presented an OR of 3.77 (95% CI 1.32-10.74; P = .013). For each incremental increase in the anxiety score, there was an 8% increase in the probability of BMG (OR=1.08; 95% CI 1.03-1.14; P = .007).

CONCLUSIONS

Anxiety increases the risk of BMG. Moreover, the occurrence of BMG was associated with polymorphisms in the 5HTT gene.

摘要

目的

本病例对照研究旨在探讨良性游走性舌炎（BMG）是否与儿茶酚-O-甲基转移酶（COMT）和 5-羟色胺转运体（5HTT）基因多态性及焦虑有关。

研究设计

本研究纳入了 43 例 BMG 患者和 114 例无 BMG 病史的患者。我们使用汉密尔顿焦虑量表（HAM-A）对个体的焦虑程度进行评估。我们从颊黏膜细胞中提取 DNA，分析 COMT 和 5HTT 的基因多态性。我们使用 SPSS 软件（SPSS Inc.，芝加哥，IL）和 STATA（StataCorp，德克萨斯州立大学，College Station，TX）进行统计评估。α 值设为 0.05。

结果

病例组的整体焦虑水平明显高于对照组（P < 0.001）。在调整后的多因素逻辑回归中，COMT 标志物与 BMG 无关。5HTT 基因 rs3813034 中的 CC 基因型个体的比值比（OR）为 2.85（95%置信区间 [CI]，1.03-7.82；P=0.042）。5HTT 基因 rs1042173 中的 TT 基因型个体的 OR 为 3.77（95% CI，1.32-10.74；P=0.013）。焦虑评分每增加 1 分，BMG 的概率增加 8%（OR=1.08；95% CI，1.03-1.14；P=0.007）。