阿司匹林未能预防大型亚洲队列人群的胰腺癌。
Aspirin Does Not Prevent Pancreatic Cancer in a Large Asian Cohort.
机构信息
Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.
Department of Family Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, South Korea.
出版信息
Cancer Epidemiol Biomarkers Prev. 2019 Apr;28(4):826-828. doi: 10.1158/1055-9965.EPI-18-1325. Epub 2019 Jan 14.
BACKGROUND
Evidence has suggested that aspirin reduces the incidence of several cancers, but these benefits may not occur with pancreatic cancer.
METHODS
A 12-year nationwide longitudinal cohort merged with the health checkup data was divided into "exposure ascertainment period" and "outcome ascertainment period" to avoid immortal time bias. The daily defined dose system was used to indicate the drug exposure.
RESULTS
We found no significant association between aspirin use and incident pancreatic cancer based on HR.
CONCLUSIONS
Aspirin does not prevent pancreatic cancer.
IMPACT
A large Asian cohort study with reliable medication information affirms no impact of aspirin on pancreatic cancer development.
背景
有证据表明阿司匹林可降低多种癌症的发病率，但对于胰腺癌，这些益处可能并不存在。
方法
将一项为期 12 年的全国性纵向队列研究与健康检查数据合并，分为“暴露确定期”和“结局确定期”，以避免不死时间偏倚。采用每日规定剂量系统表示药物暴露情况。
结果
基于 HR，我们发现阿司匹林的使用与胰腺癌的发生之间没有显著关联。
结论
阿司匹林不能预防胰腺癌。
影响
这项基于可靠药物信息的大型亚洲队列研究证实，阿司匹林对胰腺癌的发展没有影响。
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