Gera Anjali, Kamson David Olayinka, Villaflor Victoria M, Lukas Rimas V
Department of Neurology, University of Chicago, Chicago, Illinois, USA.
Section of Hematology & Oncology, Northwestern University, Chicago, Illinois, USA.
Lung Cancer Manag. 2017 Jul;6(1):9-16. doi: 10.2217/lmt-2016-0020. Epub 2017 Jul 14.
Diagnosis of paraneoplastic neurologic disorder (PND) synthesizes the clinical picture (including the temporal relationship to the cancer diagnosis), detection of onconeural antibodies and exclusion of alternative causes. The mainstay of brain imaging of PNDs is MRI. There is also an increasingly recognized role of PET using radiotracer F-Fluorodeoxyglucose (FDG) in the evaluation of the brain. We describe a 67-year-old female with a 50-year smoking history and small-cell lung cancer developing subacute encephalopathy with MRI and PET abnormalities identifying paraneoplastic encephalitis. PET may complement conventional tools in diagnosing a subset of patients with PND.
副肿瘤性神经系统疾病（PND）的诊断综合了临床表现（包括与癌症诊断的时间关系）、肿瘤神经抗体的检测以及排除其他病因。PND脑部成像的主要手段是MRI。正电子发射断层显像（PET）使用放射性示踪剂F-氟脱氧葡萄糖（FDG）在脑部评估中的作用也越来越受到认可。我们描述了一名67岁女性，有50年吸烟史，患小细胞肺癌并发展为亚急性脑病，MRI和PET异常显示为副肿瘤性脑炎。PET在诊断一部分PND患者时可作为传统工具的补充。
