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2
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Clin Respir J. 2018 Mar;12(3):1150-1159. doi: 10.1111/crj.12644. Epub 2017 May 10.
3
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Genome Med. 2017 Apr 19;9(1):34. doi: 10.1186/s13073-017-0424-2.
4
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Lung Cancer. 2017 Jan;103:52-57. doi: 10.1016/j.lungcan.2016.11.018. Epub 2016 Nov 28.
5
Maintenance erlotinib versus erlotinib at disease progression in patients with advanced non-small-cell lung cancer who have not progressed following platinum-based chemotherapy (IUNO study).对于接受铂类化疗后未进展的晚期非小细胞肺癌患者,疾病进展时维持使用厄洛替尼与使用厄洛替尼的对比研究(IUNO研究)。
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6
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晚期肺鳞状细胞癌:治疗选择、未来方向、未满足的需求及单中心调查结果

Advanced squamous lung cancer: therapeutic options, future directions, unmet needs and results of a monocentric survey.

作者信息

Bertaglia Valentina, Vallone Stefania, Pacchiana Maria Vittoria, Novello Silvia

机构信息

Department of Oncology, University of Turin, San Luigi Hospital, Orbassano, Turin, Italy.

Women Against Lung Cancer in Europe, Orbassano, Turin, Italy.

出版信息

Lung Cancer Manag. 2017 Dec;6(3):93-107. doi: 10.2217/lmt-2017-0011. Epub 2017 Dec 1.

DOI:10.2217/lmt-2017-0011
PMID:30643575
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6310352/
Abstract

Lung cancer is the leading cause of cancer-related deaths in worldwide, and NSCLC represents around 85% of all lung cancers. Squamous cell lung cancer (SqCLC) is the second most common subtype and it is challenging to treat. New options have been discovered but progresses are still limited for the lack of 'druggable' mutations. Specific resources for SqCLC are limited and this condition affects treatment and outcomes. This paper describes available and emerging therapeutic options and resources that may help patients to face their disease. We have also performed a monocentric survey collecting information about smoking habit and sense of guilty and analyzed the possibility for patients to find helpful sources for their disease. The results suggest that more materials focused on SqCLC are still needed.

摘要

肺癌是全球癌症相关死亡的主要原因,非小细胞肺癌约占所有肺癌的85%。肺鳞状细胞癌(SqCLC)是第二常见的亚型,治疗具有挑战性。虽然已发现新的治疗选择,但由于缺乏“可靶向”突变,进展仍然有限。SqCLC的特定资源有限,这一情况影响了治疗和预后。本文描述了可能有助于患者应对疾病的现有和新兴治疗选择及资源。我们还进行了一项单中心调查,收集有关吸烟习惯和负罪感的信息,并分析患者找到针对其疾病的有用信息来源的可能性。结果表明,仍需要更多聚焦于SqCLC的资料。