革兰氏阴性菌感染的治疗。

Treatment of gram-negative infections.

作者信息

Brown S A

机构信息

Department of Veterinary Physiology and Pharmacology, Texas Veterinary Medical Center, Texas A&M University College of Veterinary Medicine, College Station.

出版信息

Vet Clin North Am Small Anim Pract. 1988 Nov;18(6):1141-65. doi: 10.1016/s0195-5616(88)50128-6.

DOI:10.1016/s0195-5616(88)50128-6

PMID:3064388

Abstract

The armamentarium of antimicrobial agents for treatment of gram-negative infections has increased tremendously over the past 10 to 15 years. This article considers the characteristics of gram-negative bacteria. Also discussed are the mechanism of action, spectrum of activity, toxicity, disposition, and drug interactions of various antimicrobial agents, including the aminoglycosides, beta-lactam antibiotics, quinolones, tetracyclines, chloramphenicol, and the polymyxins.

摘要

在过去10到15年里，用于治疗革兰氏阴性菌感染的抗菌药物种类大幅增加。本文探讨了革兰氏阴性菌的特性。同时还讨论了包括氨基糖苷类、β-内酰胺类抗生素、喹诺酮类、四环素类、氯霉素和多粘菌素在内的各种抗菌药物的作用机制、活性谱、毒性、代谢及药物相互作用。