Department of Radiology, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu, 610041, Sichuan, China.
Sichuan Primed Shines Bio-tech Co., Ltd., Chengdu, China.
Eur Radiol. 2019 Jun;29(6):3006-3016. doi: 10.1007/s00330-018-5950-9. Epub 2019 Jan 14.
To detect diffuse myocardial fibrosis in different severity levels of left ventricular diastolic dysfunction (DD) in spontaneous type 2 diabetes mellitus (T2DM) rhesus monkeys.
Eighteen spontaneous T2DM and nine healthy monkeys were studied. Echocardiography was performed for diastolic function classification. Cardiac magnetic resonance (CMR) imaging was performed to obtain extracellular volume fraction (ECV) maps and T1ρ maps at two different spin-locking frequencies. ECV values, T1ρ values, and myocardial fibrosis index (mFI) values which are based on the dispersion of T1ρ, were calculated. Global peak diastolic longitudinal strain rates (GSrL) were also obtained.
Echocardiography results showed mild DD in nine T2DM monkeys and moderate DD in the other nine. The global ECV values were significantly different among healthy animals as compared with animals with mild DD or moderate DD, and the ECV values of animals with moderate DD were significantly higher as compared with those of mild DD. The mFI values increased progressively from healthy animals to those with mild DD and then to those with moderate DD. Diastolic function indicators (e.g., early diastolic mitral annulus velocity, GSrL) correlated well with ECV and mFI.
Monkeys with T2DM exhibit increased ECV, T1ρ, and mFI values, which may be indicative of the expansion of extracellular volume and the deposition of excessive collagen. T1ρ mapping may have the potential to be used for diffuse myocardial fibrosis assessment.
• Monkeys with T2DM exhibit increased ECV, T1ρ, and mFI values, which may be indicative of the expansion of extracellular volume and the deposition of excessive collagen. • The relationship between diastolic dysfunction and diffuse myocardial fibrosis may be demonstrated by imaging markers. • Non-contrast T1ρ mapping may have the potential to be used for diffuse myocardial assessment.
检测不同严重程度左心室舒张功能障碍（DD）的自发性 2 型糖尿病（T2DM）恒河猴的弥漫性心肌纤维化。
研究了 18 只自发性 T2DM 猴和 9 只健康猴。行超声心动图检查进行舒张功能分类。行心脏磁共振（CMR）成像以获得细胞外容积分数（ECV）图和两个不同自旋锁定频率的 T1ρ 图。计算 ECV 值、T1ρ 值和基于 T1ρ 离散的心肌纤维化指数（mFI）值。还获得了整体峰值舒张纵向应变率（GSrL）。
超声心动图结果显示，9 只 T2DM 猴存在轻度 DD，另外 9 只存在中度 DD。与轻度 DD 或中度 DD 的动物相比，健康动物的整体 ECV 值有显著差异，中度 DD 动物的 ECV 值显著高于轻度 DD 动物。mFI 值从健康动物逐渐升高至轻度 DD 动物，然后再升高至中度 DD 动物。舒张功能指标（如早期舒张二尖瓣环速度、GSrL）与 ECV 和 mFI 相关性良好。
T2DM 猴存在 ECV、T1ρ 和 mFI 值升高，可能提示细胞外容积扩张和胶原过度沉积。T1ρ 图可能具有评估弥漫性心肌纤维化的潜力。
• T2DM 猴存在 ECV、T1ρ 和 mFI 值升高，可能提示细胞外容积扩张和胶原过度沉积。
• 舒张功能障碍与弥漫性心肌纤维化之间的关系可以通过影像学标志物来证明。
• 无需对比剂的 T1ρ 图可能具有评估弥漫性心肌的潜力。
