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急性非特异性下腰痛的医学管理:不同医学治疗方法的比较,一家中心的回顾性分析。

Medical management of acute non-specific low back pain: comparison of different medical treatments, one center's retrospective analysis.

机构信息

Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.

Division of Spinal Surgery, Catholic University of Sacred Heart, Rome, Italy.

出版信息

J Biol Regul Homeost Agents. 2018 Nov-Dec;32(6 Suppl. 1):121-129.

Abstract

Within the developed countries, low back pain and related ailments represent one of the most relevant conditions, affecting both health and socio-economic systems. Non-specific acute low back pain (nsALBP) could represent either an isolated event or the presenting symptom of an underlying condition. Its management is usually medical and radiological investigations should be avoided. However, a general agreement on the best pharmacological treatment is still missing. In the present study, we retrospectively collected patients' data from the institutional database. Two different medical treatments were recognized and groups consequently set. Outcomes were the clinical status, measured using the visual analogue scale (VAS) score for back pain, the use rate of rescue drugs, side effects related to medical treatment, compliance to the treatment, and global satisfaction. The pharma blending of Tramadol 75 mg and Dexketoprofen 25 mg (available blended in a single tablet), resulted effective in the nsALBP management, with less side effects and rescue-drug use along with a higher compliance. Furthermore, patient satisfaction in this treatment group was significatively higher. Many different medical treatments have been investigated and reported in nsALBP management during the last decades. Associations of different drugs are the most common protocols, even though there is no general agreement. Tramadol and Dexketoprofen provide a good clinical result, fewer side effects and a long-lasting and more effective painkiller action, reducing the use of rescue drugs. Moreover, our results suggest that a single tab may provide a higher compliance rate.

摘要

在发达国家,下背痛及相关疾病是最相关的病症之一,影响健康和社会经济系统。非特异性急性下背痛(nsALBP)可能是一个孤立的事件,也可能是潜在疾病的表现症状。其管理通常是医学和放射学调查应避免。然而,对于最佳药物治疗仍然缺乏普遍的共识。在本研究中,我们从机构数据库中回顾性地收集了患者的数据。识别出两种不同的医疗治疗方法,并相应地设置了组。结果是临床状况,使用下背痛视觉模拟评分(VAS)测量,急救药物的使用率,与药物治疗相关的副作用,对治疗的依从性和总体满意度。曲马多 75 毫克和右旋酮洛芬 25 毫克(可混合在一片)的混合药物治疗在 nsALBP 管理中是有效的,副作用和急救药物的使用较少,同时具有较高的依从性。此外,该治疗组的患者满意度显著更高。在过去几十年中,已经研究和报道了许多不同的药物治疗方法在 nsALBP 管理中的应用。不同药物的联合应用是最常见的方案,尽管没有普遍的共识。曲马多和右旋酮洛芬提供了良好的临床效果,副作用较少,且止痛作用持久而有效,减少了急救药物的使用。此外,我们的结果表明,单一片剂可能会提高患者的依从性。

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