Braga Madalena, Moleiro Maria Lúcia, Guedes-Martins Luís
Instituto de Ciencias Biomedicas Abel Salazar, University of Porto, Porto, Portugal.
Departamento da Mulher e da Medicina Reprodutiva, Centro Materno Infantil do Norte, Centro Hospitalar do Porto EPE, Porto, Portugal.
Curr Cardiol Rev. 2019;15(3):167-176. doi: 10.2174/1573403X15666190115142303.
The ductus venosus is a vascular shunt situated within the fetal liver parenchyma, connecting the umbilical vein to the inferior vena cava. This vessel acts as a bypass of the liver microcirculation and plays a critical role in the fetal circulation. The ductus venosus allows oxygenated and nutrient-rich venous blood to flow from the placenta to the myocardium and brain. Increased impedance to flow in the fetal ductus venosus is associated with fetal aneuploidies, cardiac defects and other adverse pregnancy outcomes. This review serves to improve our understanding of the mechanisms that regulate the blood flow redistribution between the fetal liver circulation and fetal heart and the clinical significance of the ductus venosus waveform as generated by pressure-volume changes in the fetal heart.
静脉导管是位于胎儿肝实质内的一个血管分流通道，连接脐静脉和下腔静脉。该血管起到绕过肝脏微循环的作用，在胎儿循环中发挥关键作用。静脉导管使富含氧气和营养物质的静脉血从胎盘流向心肌和大脑。胎儿静脉导管内血流阻力增加与胎儿非整倍体、心脏缺陷及其他不良妊娠结局相关。本综述旨在增进我们对调节胎儿肝脏循环与胎儿心脏之间血流重新分布的机制以及胎儿心脏压力 - 容积变化所产生的静脉导管波形的临床意义的理解。
