School of Marine Sciences, Sun Yat-Sen University, Guangzhou 510006, China.
Chem Commun (Camb). 2019 Jan 29;55(10):1438-1441. doi: 10.1039/c8cc08970a.
Trichobamide A (1), a novel pyrrocidine alkaloid with an unprecedented tetrahydro-5H-furo[2,3-b]pyrrol-5-one moiety, was isolated from the ascidian-derived fungus Trichobotrys effuse 4729. Trichobamide A (1) showed significant inhibition of the proliferation of two glioma cell lines, U251 and SNB19. It induced the up-regulation of P53 expression, which in turn induces the up-regulation of downstream pro-apoptotic gene expression and the down-regulation of anti-apoptotic gene expression.
从来源于被囊动物的真菌 Trichobotrys effuse 4729 中分离得到新型吡咯里西啶生物碱 Trichobamide A（1），其具有一个前所未有的四氢-5H-呋喃[2,3-b]吡咯-5-酮部分。Trichobamide A（1）对两种神经胶质瘤细胞系 U251 和 SNB19 的增殖具有显著的抑制作用。它诱导 P53 表达上调，进而诱导下游促凋亡基因表达上调和抗凋亡基因表达下调。
