Momen Tooba, Saneian Hossein, Amini Nilufar
Department of Asthma, Allergy and Clinical Immunology, Child Growth and Development Research Center, Research Institute of Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Pediatric Gastroenterology, Child Growth and Development Research Center, Research Institute of Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
Iran J Allergy Asthma Immunol. 2018 Dec 3;17(6):533-539.
Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease isolated to the esophagus Food allergy is thought to play an important role in the pathophysiology of EOE. The aim of this study is to evaluate demographic features and sensitivity of patients with reference to common food allergens. Children with documented EoE were enlisted for this study. Skin prick test and patch test were done for all participants. Each test contained common food allergens. Other tests, such as evaluation of total IgE and eosinophil count, were also done. A total of 30 patients (the mean age of participants was 3±6 years) with 6 months to 15 years documented EoE participated in this study. The mean duration of symptoms was 2 years. Association with other allergic disorders was seen in 16 (32%) patients [Asthma in 8 (26.7%), allergic rhinitis in 5 (16.7%) and eczema in 3 (10%)]. The mean level of total IgE was 413.5±505.5 (IU/ML): total IgE level was above normal range for age in 17 children. The mean level of eosinophil was 372.2±305.2, and eosinophilia was seen in 11 patients (36.7%). The skin prick test and patch test findings showed that 28 patients (93%) and 17 of 30 patients (56.6%) tested positive to foods respectively. The most common positive skin prick test was for sesame and walnut. Patch test showed that the most common positive test was for fish. Evaluating the symptoms indicated that vomiting (70%) is the most prevalent symptom in patients; the less prevalent symptom was dysphagia (3.3%). Other prevalent symptoms were subsequent abdominal pain (33.3%), gaining weight failure (33.3%), heartburn (16.6%), cough (10%), fecal impaction (10%), and constipation (6.66%). Our series confirms the high degree of atopy in Iranian children with EoE. These patients seem to be polysensitized to several food allergens Because of different eating cultures in different countries, considering special food in selecting allergens for allergic tests is needed.
嗜酸性粒细胞性食管炎（EoE）是一种局限于食管的慢性免疫介导性疾病。食物过敏被认为在EoE的病理生理学中起重要作用。本研究的目的是评估患者的人口统计学特征以及对常见食物过敏原的敏感性。确诊为EoE的儿童被纳入本研究。对所有参与者进行了皮肤点刺试验和斑贴试验。每项试验都包含常见食物过敏原。还进行了其他检查，如总IgE和嗜酸性粒细胞计数评估。共有30例患者（参与者的平均年龄为3±6岁），有6个月至15年确诊EoE的记录，参与了本研究。症状的平均持续时间为2年。16例（32%）患者出现与其他过敏性疾病的关联[8例（26.7%）患有哮喘，5例（16.7%）患有过敏性鼻炎，3例（10%）患有湿疹]。总IgE的平均水平为413.5±505.5（IU/ML）：17名儿童的总IgE水平高于其年龄的正常范围。嗜酸性粒细胞的平均水平为372.2±305.2，11例患者（36.7%）出现嗜酸性粒细胞增多。皮肤点刺试验和斑贴试验结果显示，分别有28例患者（93%）和30例患者中的17例（56.6%）对食物检测呈阳性。最常见的阳性皮肤点刺试验针对芝麻和核桃。斑贴试验显示，最常见的阳性试验针对鱼类。对症状的评估表明，呕吐（70%）是患者中最普遍的症状；较不普遍的症状是吞咽困难（3.3%）。其他普遍症状包括继发性腹痛（33.3%）、体重增加失败（33.3%）、烧心（16.6%）、咳嗽（10%）、粪便嵌塞（10%）和便秘（6.66%）。我们的系列研究证实了伊朗EoE儿童的高度特应性。这些患者似乎对多种食物过敏原多敏。由于不同国家的饮食文化不同，在选择用于过敏试验的过敏原时需要考虑特殊食物。
