类风湿关节炎的免疫抑制治疗。
Immunosuppressive therapy in rheumatoid arthritis.
作者信息
Rainer F
机构信息
Medizinischen Universitätsklinik Graz.
出版信息
Acta Med Austriaca. 1988;15(5):137-40.
Immunosuppressive drugs are used since 1951 for the treatment of rheumatoid arthritis. The most extensive used ones are azathioprine, cyclophosphamide, chlorambucil and methotrexate. The efficacy of these immunosuppressive drugs is clinical proven. Nevertheless it is necessary to use these drugs in severe disease only that has failed to respond to less toxic agents. The number of severe side effects is higher and the consequences of this therapy concerning cancerogenity is not clear yet. The efficacy and side effects of these drugs are discussed and guidelines for using immunosuppressive drugs in the treatment of rheumatoid arthritis are given.
自1951年起，免疫抑制药物就被用于治疗类风湿性关节炎。使用最为广泛的是硫唑嘌呤、环磷酰胺、苯丁酸氮芥和甲氨蝶呤。这些免疫抑制药物的疗效已得到临床证实。然而，仅在对毒性较小的药物无反应的严重疾病中才需要使用这些药物。严重副作用的数量较多，而且这种疗法在致癌性方面的后果尚不清楚。本文讨论了这些药物的疗效和副作用，并给出了在类风湿性关节炎治疗中使用免疫抑制药物的指南。
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