Zielinski C, Müller C, Smolen J
II. Medizinischen Universitätsklinik Wien.
Acta Med Austriaca. 1988;15(5):155-8.
The effectivity of a combination of various plasma exchange regimens in combination with immunosuppressive medication consisting of corticosteroids and cyclophosphamide was tested in patients with severe systemic lupus erythematosus (SLE) the symptoms of which were found to be refractory to conventional immunosuppressive treatment administered orally. The patients were then submitted in a controlled manner to the following treatment modalities: 1. consecutive plasmapheresis (plasma exchanges every 2 to 3 days during a period of 2 to 3 weeks) with a continuation of immunosuppressive therapy administered orally; 2. chronic intermittent treatment (once per week) with parallel immunosuppression; 3. 2 plasmaphereses followed by an i.v. cyclophosphamide bolus. Only the third approach resulted in a stable and persistent clinical and serological improvement of disease activity.
在重症系统性红斑狼疮（SLE）患者中测试了各种血浆置换方案与由皮质类固醇和环磷酰胺组成的免疫抑制药物联合使用的有效性，这些患者的症状对口服常规免疫抑制治疗无效。然后，以对照方式对患者进行以下治疗方式：1. 连续血浆置换（在2至3周内每2至3天进行一次血浆置换）并继续口服免疫抑制治疗；2. 慢性间歇治疗（每周一次）并同时进行免疫抑制；3. 进行2次血浆置换，然后静脉注射大剂量环磷酰胺。只有第三种方法导致疾病活动度在临床和血清学上得到稳定且持久的改善。
