Watanabe M, Hotchi M, Nagasaki M
Department of Pathology, Shinshu University School of Medicine, Matsumoto, Japan.
Acta Pathol Jpn. 1988 Jun;38(6):769-80. doi: 10.1111/j.1440-1827.1988.tb02348.x.
An autopsy case of a 52-year-old Japanese male, who died of disseminated histoplasmosis, is reported. He had received a cadaveric renal allograft 4 years prior to death. The donor was a 33-year-old American negro male, who had resided in Texas. The patient had been treated with immunosuppressive drugs after renal transplantation, and mycotic pneumonia developed 3 months before death. At autopsy, acute necrotizing lesions composed of histiocytes were observed in the transplanted kidney, lungs, prostate gland and various lymph nodes. Abundant yeast-like fungal elements, measuring 2-5 micron in diameter, were engulfed by the histiocytes, and were identified as Histoplasma capsulatum by the immunoperoxidase method. The transplanted kidney was considered to have been the source of the infection.
报告了一例52岁日本男性因播散性组织胞浆菌病死亡的尸检病例。他在死亡前4年接受了尸体肾移植。供体是一名33岁居住在得克萨斯州的美国黑人男性。患者肾移植后接受了免疫抑制药物治疗，在死亡前3个月发生了霉菌性肺炎。尸检时，在移植肾、肺、前列腺和各种淋巴结中观察到由组织细胞组成的急性坏死性病变。组织细胞吞噬了大量直径为2 - 5微米的酵母样真菌成分，通过免疫过氧化物酶法鉴定为荚膜组织胞浆菌。移植肾被认为是感染源。
