Go K G
Department of Neurosurgery, University Hospital Groningen, The Netherlands.
Acta Neurochir (Wien). 1988;95(1-2):25-7. doi: 10.1007/BF01793078.
A survey is given on the history of the discovery of the blood-brain barrier, of its functions and of its clinical importance. Also attempts to circumvent or disrupt the barrier with the aim of introducing therapeutic or diagnostic agents into the brain tissue have been reported. Finally the possible negative effects of lasting barrier defects in transplanted foetal tissue are mentioned.
本文综述了血脑屏障的发现史、功能及其临床意义。也有报道称,为了将治疗或诊断药物引入脑组织,人们尝试绕过或破坏血脑屏障。最后,文中提到了移植胎儿组织中持续存在的屏障缺陷可能产生的负面影响。