Zoppi A, Sudano S, Bosco L, Spata M, Fogari R
Department of Internal Medicine and Therapeutics, S. Matteo Hospital, University of Pavia, Italy.
Am J Med. 1988 Mar 11;84(3A):145-7. doi: 10.1016/0002-9343(88)90222-7.
The aim of this study was to evaluate the effects of short-term captopril administration on the response to cold pressor testing in normotensive and hypertensive subjects. Cold pressor testing was performed in 15 normotensive subjects and 15 hypertensive patients before and 90 minutes after captopril administration. Blood pressure and heart rate were measured before testing and at one-minute intervals from the beginning of cold pressor testing. Systolic time intervals were also assessed before and after testing. Captopril did not affect pressor responses to cold pressor testing in normotensive subjects or hypertensive patients. Basal heart rate (before testing) did not change, despite the decrease in blood pressure and showed a smaller increase in response to cold pressor testing in normotensive subjects, suggesting that captopril might interfere with arterial baroreflexes. The systolic time intervals were not modified by captopril except isometric contraction time; its basal value was reduced by captopril in both normotensive subjects and hypertensive patients. Cold exposure caused a similar increase in isometric contraction time before and after captopril in normotensive subjects, and the increase in isometric contraction time in hypertensive patients was greater. These findings suggest that captopril did not affect cardiac performance, indeed improving it, at least in basal conditions.
本研究的目的是评估短期服用卡托普利对正常血压和高血压受试者冷加压试验反应的影响。在15名正常血压受试者和15名高血压患者中，于服用卡托普利前及服用后90分钟进行冷加压试验。在试验前以及从冷加压试验开始每隔一分钟测量血压和心率。还在试验前后评估收缩期时间间期。卡托普利对正常血压受试者或高血压患者的冷加压试验升压反应无影响。尽管血压下降，但基础心率（试验前）未改变，且正常血压受试者对冷加压试验的心率增加较小，提示卡托普利可能干扰动脉压力反射。除等长收缩时间外，收缩期时间间期未被卡托普利改变；在正常血压受试者和高血压患者中，其基础值均被卡托普利降低。在正常血压受试者中，冷暴露导致服用卡托普利前后等长收缩时间有相似增加，且高血压患者等长收缩时间的增加更大。这些发现提示，卡托普利至少在基础状态下不影响心脏功能，实际上还改善了心脏功能。
