Bjørneboe G E, Johnsen J, Bjørneboe A, Marklund S L, Skylv N, Høiseth A, Bache-Wiig J E, Mørland J, Drevon C A
National Institute of Forensic Toxicology, Oslo, Norway.
Alcohol Clin Exp Res. 1988 Dec;12(6):806-10. doi: 10.1111/j.1530-0277.1988.tb01350.x.
The effect of ethanol consumption on serum concentration of alpha-tocopherol, erythrocyte activities of superoxide dismutase, glutathione peroxidase, and catalase were studied in 34 male alcoholics and 35 age-matched controls. Serum concentration of alpha-tocopherol was 30% lower in the alcoholics as compared to the controls (p less than 0.001). No significant difference was found in erythrocyte activities of Cu-Zn-containing superoxide dismutase, glutathione peroxidase, or catalase between the groups. Of the 12 alcoholics with subnormal serum alpha-tocopherol, 50% had concomitant neurological clinical scores and cerebellar atrophy, and their neurological scores were significantly higher (82%) than for alcoholics with normal alpha-tocopherol levels (p less than 0.03). However, no significant correlation was observed between levels of alpha-tocopherol and neurological clinical scores or cerebellar atrophy. When entering the study, alcoholics and controls were each randomized into two separate groups, receiving vitamin E supplementation (100 mg/day) or placebo capsules for 10 days, respectively. In the four subgroups, alpha-tocopherol levels increased only in alcoholics receiving vitamin E supplementation (23%) (p less than 0.001). The reduced serum levels of alpha-tocopherol in alcoholics may be normalized by vitamin E supplementation.
在34名男性酗酒者和35名年龄匹配的对照者中，研究了乙醇摄入对血清α-生育酚浓度、红细胞超氧化物歧化酶、谷胱甘肽过氧化物酶和过氧化氢酶活性的影响。与对照组相比，酗酒者血清α-生育酚浓度低30%（p<0.001）。两组之间含铜锌超氧化物歧化酶、谷胱甘肽过氧化物酶或过氧化氢酶的红细胞活性未发现显著差异。在血清α-生育酚水平低于正常的12名酗酒者中，50%伴有神经学临床评分和小脑萎缩，且他们的神经学评分显著高于（82%）α-生育酚水平正常的酗酒者（p<0.03）。然而，未观察到α-生育酚水平与神经学临床评分或小脑萎缩之间存在显著相关性。在进入研究时，酗酒者和对照者各自随机分为两个单独的组，分别接受维生素E补充剂（100mg/天）或安慰剂胶囊，持续10天。在四个亚组中，仅接受维生素E补充剂的酗酒者的α-生育酚水平升高（23%）（p<0.001）。酗酒者血清α-生育酚水平降低可能通过补充维生素E得以正常化。
