Sachdeva Ashwani Kumar, Penumadu Prasanth, Kohli Pavneet, Dubashi Biswajit, Munuswamy Hemachandren
1 Balco Medical Center, Raipur, India.
2 Department of Surgical Oncology, Jawaharlal Institute of Postgraduate Medical Education & Research, Pondicherry, India.
Asian Cardiovasc Thorac Ann. 2019 Feb;27(2):98-104. doi: 10.1177/0218492318823345. Epub 2019 Jan 15.
Growing teratoma syndrome is a rare phenomenon seen in nonseminomatous germ cell tumors after chemotherapy, where the tumor grows paradoxically despite normalization of tumor markers. It has been found in various locations, most commonly, the retroperitoneum in association with metastatic disease. The occurrence of growing teratoma syndrome in a mediastinal primary is very rare and there are only a few reports in the literature.
In a retrospective review, out of 12 patients with mediastinal involvement by a germ cell tumor, 5 had a primary from the mediastinum. We present a series of 3 cases of primary germ cell tumor of the mediastinum, which after chemotherapy, fulfilled the criteria for growing teratoma syndrome and were managed with surgical excision.
Development of growing teratoma syndrome in a primary mediastinal germ cell tumor is extremely rare. Its awareness and early detection can lead to successful surgical excision and long-term cure.
生长性畸胎瘤综合征是化疗后非精原细胞性生殖细胞肿瘤中罕见的现象，尽管肿瘤标志物恢复正常，但肿瘤却反常生长。该综合征可见于多个部位，最常见于伴有转移性疾病的腹膜后。原发性纵隔生长性畸胎瘤综合征极为罕见，文献中仅有少数报道。
在一项回顾性研究中，12例生殖细胞肿瘤累及纵隔的患者中，5例原发于纵隔。我们报告了3例纵隔原发性生殖细胞肿瘤病例，这些病例在化疗后符合生长性畸胎瘤综合征的标准，并接受了手术切除治疗。
原发性纵隔生殖细胞肿瘤发生生长性畸胎瘤综合征极为罕见。对其有所认识并早期发现可实现成功的手术切除及长期治愈。
