新型亚硝基脲S10036在啮齿动物肿瘤中的抗肿瘤活性。
Antitumor activity of the novel nitrosourea S10036 in rodent tumors.
作者信息
Filippeschi S, Colombo T, Bassani D, De Francesco L, Arioli P, D'Incalci M, Bartosek I, Guaitani A
机构信息
Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
出版信息
Anticancer Res. 1988 Nov-Dec;8(6):1351-4.
The activity of the novel anticancer agent diethyl 1-3-(chloroethyl)-3-nitrosoureido ethyl phosphonate (S10036) was investigated on several rodent tumors. S10036 showed a good efficacy, comparable to that of the anticancer agent BCNU, against i.p transplanted P388 and L1210 leukemias. S10036 was very effective against the primary tumor and metastases of i.m transplanted M5076 reticular cell sarcoma of the mouse and against subline A of the Walker carcinoma of the rat. It was inactive against rodent tumors resistant to BCNU such as L1210/BCNU, ICIG-Ci4 murine fibrosarcoma and the Walker carcinoma subline B in the rat.
研究了新型抗癌剂二乙基 1-3-(氯乙基)-3-亚硝基脲基乙基膦酸酯（S10036）对几种啮齿动物肿瘤的活性。S10036 对腹腔注射移植的 P388 和 L1210 白血病显示出良好的疗效，与抗癌剂卡莫司汀相当。S10036 对小鼠肌肉注射移植的 M5076 网状细胞肉瘤的原发性肿瘤和转移灶以及大鼠 Walker 癌 A 亚系非常有效。它对卡莫司汀耐药的啮齿动物肿瘤如 L1210/BCNU、ICIG-Ci4 小鼠纤维肉瘤和大鼠 Walker 癌 B 亚系无活性。
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