SPECTRA 协作 OMERACT 工作组：高分辨率外周定量计算机断层扫描评估关节间隙结局的结构有效性。
The SPECTRA Collaboration OMERACT Working Group: Construct Validity of Joint Space Outcomes with High-resolution Peripheral Quantitative Computed Tomography.
机构信息
From the Department of Radiology, and Department of Medicine, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary; Biomedical Engineering Graduate Program, Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Rheumatology and Clinical Immunology, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Department of Biomedical Engineering, The University of Melbourne, Parkville, Australia; Leeds Institute for Rheumatic and Musculoskeletal Medicine, University of Leeds and UK National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds, UK.
S.L. Manske, PhD, Department of Radiology, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, and Biomedical Engineering Graduate Program, Department of Radiology, Cumming School of Medicine, University of Calgary; S.C. Brunet, BSc, Department of Radiology, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, and Biomedical Engineering Graduate Program, Department of Radiology, Cumming School of Medicine, University of Calgary; S. Finzel, MD, Department of Rheumatology and Clinical Immunology, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg; K.S. Stok, PhD, Department of Biomedical Engineering, The University of Melbourne; P.G. Conaghan, MD, PhD, Leeds Institute for Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre; S.K. Boyd, PhD, Department of Radiology, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, and Biomedical Engineering Graduate Program, Department of Radiology, Cumming School of Medicine, University of Calgary; C. Barnabe, MSc, MD, Department of Medicine, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary.
出版信息
J Rheumatol. 2019 Oct;46(10):1369-1373. doi: 10.3899/jrheum.180870. Epub 2019 Jan 15.
OBJECTIVE
We assessed construct validity of high-resolution peripheral quantitative computed tomography (HR-pQCT) joint space outcomes by comparison with radiographs in patients with rheumatoid arthritis.
METHODS
In 43 patients, quantitative, volumetric, HR-pQCT measurements were compared with ordinal Sharp/van der Heijde scoring (SvdH) in the 2nd and 3rd metacarpophalangeal joints.
RESULTS
Generalized estimating equations showed that joint space minimum, SD, and asymmetry by HR-pQCT were associated with SvdH scores (p < 0.05). There was a considerable range in HR-pQCT measurements at SvdH equal to 0.
CONCLUSION
HR-pQCT demonstrated construct validity outcomes and provides improved 3-D visualization of joint space.
目的
通过与类风湿关节炎患者的 X 光片进行比较，评估高分辨率外周定量 CT（HR-pQCT）关节间隙结果的结构效度。
方法
在 43 名患者中，对定量、容积 HR-pQCT 测量值与第二和第三掌指关节的序数 Sharp/van der Heijde 评分（SvdH）进行了比较。
结果
广义估计方程显示，HR-pQCT 的关节间隙最小、SD 和不对称与 SvdH 评分相关（p<0.05）。在 SvdH 等于 0 时，HR-pQCT 的测量值有相当大的范围。
结论
HR-pQCT 显示了结构效度的结果，并提供了关节间隙的改进 3-D 可视化。
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