McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Osteoporos Int. 2020 Sep;31(9):1607-1627. doi: 10.1007/s00198-020-05438-5. Epub 2020 May 26.
The application of high-resolution peripheral quantitative computed tomography (HR-pQCT) to assess bone microarchitecture has grown rapidly since its introduction in 2005. As the use of HR-pQCT for clinical research continues to grow, there is an urgent need to form a consensus on imaging and analysis methodologies so that studies can be appropriately compared. In addition, with the recent introduction of the second-generation HrpQCT, which differs from the first-generation HR-pQCT in scan region, resolution, and morphological measurement techniques, there is a need for guidelines on appropriate reporting of results and considerations as the field adopts newer systems.
A joint working group between the International Osteoporosis Foundation, American Society of Bone and Mineral Research, and European Calcified Tissue Society convened in person and by teleconference over several years to produce the guidelines and recommendations presented in this document.
An overview and discussion is provided for (1) standardized protocol for imaging distal radius and tibia sites using HR-pQCT, with the importance of quality control and operator training discussed; (2) standardized terminology and recommendations on reporting results; (3) factors influencing accuracy and precision error, with considerations for longitudinal and multi-center study designs; and finally (4) comparison between scanner generations and other high-resolution CT systems.
This article addresses the need for standardization of HR-pQCT imaging techniques and terminology, provides guidance on interpretation and reporting of results, and discusses unresolved issues in the field.
自 2005 年高分辨率外周定量计算机断层扫描（HR-pQCT）应用于评估骨微观结构以来，其应用发展迅速。随着 HR-pQCT 在临床研究中的应用不断增加，迫切需要就成像和分析方法达成共识，以便能够对研究进行适当比较。此外，随着第二代 HRpQCT 的推出，其扫描区域、分辨率和形态测量技术与第一代 HR-pQCT 不同，因此需要制定有关适当报告结果的指南和考虑因素，以便该领域采用更新的系统。
国际骨质疏松基金会、美国骨矿研究学会和欧洲钙化组织学会的一个联合工作组通过现场会议和多次电话会议，历时数年制定了本文件中提出的指南和建议。
本文提供了（1）使用 HR-pQCT 对桡骨和胫骨远端部位进行成像的标准化方案概述和讨论，讨论了质量控制和操作人员培训的重要性；（2）标准化术语和报告结果的建议；（3）影响准确性和精密度误差的因素，以及对纵向和多中心研究设计的考虑；最后（4）对扫描仪代际和其他高分辨率 CT 系统进行了比较。
本文解决了 HR-pQCT 成像技术和术语标准化的需求，提供了结果解释和报告的指导，并讨论了该领域未解决的问题。
