终纹床核卵圆形部中一种新型 GPR55 介导的饱腹感信号。
A novel GPR55-mediated satiety signal in the oval Bed Nucleus of the Stria Terminalis.
机构信息
Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.
École d'optométrie, Université de Montréal, Montréal, QC, Canada.
出版信息
Neuropsychopharmacology. 2019 Jun;44(7):1274-1283. doi: 10.1038/s41386-018-0309-0. Epub 2019 Jan 7.
Abstract
Nestled within feeding circuits, the oval (ov) region of the Bed Nucleus of the Stria Terminalis (BNST) may be critical for monitoring energy balance through changes in synaptic strength. Here we report that bidirectional plasticity at ovBNST GABA synapses was tightly linked to the caloric state of male rats, seesawing between long-term potentiation (iLTP, fed) and depression (iLTD, food restricted). L-α-lysophosphatidylinositol (LPI) acting on GPR55 receptors and 2-arachidonoylglycerol (2-AG) through CB1R were respectively responsible for fed (iLTP) and food restricted (iLTD) states. Thus, we have characterized a potential gating mechanism within the ovBNST that may signal metabolic state within the rat brain feeding circuitry.
摘要
在摄食回路中，终纹床核的卵圆形（ov）区域可能通过突触强度的变化对能量平衡的监测至关重要。在这里，我们报告说，双侧杏仁核 GABA 突触的双向易化与雄性大鼠的热量状态紧密相关，在长期增强（iLTP，喂食）和抑制（iLTD，食物限制）之间摇摆。L-α-溶血磷脂酰肌醇（LPI）通过 GPR55 受体和 2-花生四烯酸甘油（2-AG）作用于 CB1R，分别负责喂食（iLTP）和食物限制（iLTD）状态。因此，我们已经描述了终纹床核内的一种潜在的门控机制，它可能在大鼠脑摄食回路内信号传递代谢状态。
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