Zaki Moushira, Kamal Sanaa, Ezzat Wafaa, Hassan Naglaa, Yousef Walaa, Ryad Hanaa, Mohamed Ramy, Youness Eman, Basha Walaa, Elhosary Yasser
Biological Anthropology Department, Medical Research Division, Giza, Egypt.
Internal Medicine Department, Medical Research Division, Giza, Egypt.
J Genet Eng Biotechnol. 2017 Dec;15(2):423-429. doi: 10.1016/j.jgeb.2017.05.002. Epub 2017 Jun 9.
Adipose tissue hormones, Adipokines, play an important role in obesity-associated complications. Apelin has recently been added to the family of adipokines. of this study was to evaluate the relationship between serum apelin levels and metabolic abnormal parameters in Egyptian obese women.
The study included 400 unrelated women; they were 200 obese women and 200 non- obese matched healthy women. All participants underwent clinical, anthropometric and biochemical examinations. Insulin resistance (IR) was determined by the homeostasis model assessment of insulin resistance (HOMA-IR). Serum apelin levels and obesity biomarkers were measured using enzyme-linked immunoassay (ELISA) kits. Fat mass was measured by Tanita Body Composition Analyzer.
Obese women showed significant higher levels of serum apelin, leptin, triglycerides, LDL-C, total cholesterol, fasting insulin HOMA-IR and blood pressure levels than controls. Significant positive correlations between apelin and leptin levels with abnormal metabolic markers were noted in obese women.
The present study suggests the significant role that might be mediated by apelin for developing abnormal metabolic parameters among Egyptian obese women.
脂肪组织激素，即脂肪因子，在肥胖相关并发症中起重要作用。Apelin最近被归入脂肪因子家族。本研究的目的是评估埃及肥胖女性血清Apelin水平与代谢异常参数之间的关系。
该研究纳入400名无亲属关系的女性，其中200名肥胖女性和200名体重匹配的健康非肥胖女性。所有参与者均接受了临床、人体测量和生化检查。采用胰岛素抵抗稳态模型评估法（HOMA-IR）测定胰岛素抵抗（IR）。使用酶联免疫吸附测定（ELISA）试剂盒检测血清Apelin水平和肥胖生物标志物。通过Tanita人体成分分析仪测量脂肪量。
肥胖女性的血清Apelin、瘦素、甘油三酯、低密度脂蛋白胆固醇、总胆固醇、空腹胰岛素HOMA-IR和血压水平显著高于对照组。在肥胖女性中，Apelin和瘦素水平与异常代谢标志物之间存在显著正相关。
本研究表明，Apelin可能在埃及肥胖女性代谢参数异常的发生中起重要作用。
