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Battling quiescence for tumor eradication: too good to be true?

作者信息

McCarty Nami

机构信息

Nami McCarty: Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases (IMM), University of Texas-Health Science Center at Houston, Houston, TX, USA.

出版信息

Oncotarget. 2018 Dec 18;9(99):37276-37277. doi: 10.18632/oncotarget.26452.

DOI:10.18632/oncotarget.26452
PMID:30647863
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6324667/
Abstract
摘要

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Osteoblast-Secreted Factors Mediate Dormancy of Metastatic Prostate Cancer in the Bone via Activation of the TGFβRIII-p38MAPK-pS249/T252RB Pathway.成骨细胞分泌因子通过激活 TGFβRIII-p38MAPK-pS249/T252RB 通路介转移前列腺癌在骨中的休眠。
Cancer Res. 2018 Jun 1;78(11):2911-2924. doi: 10.1158/0008-5472.CAN-17-1051. Epub 2018 Mar 7.
2
Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer.外泌体介导的线粒体 DNA 包装和转移调控激素治疗抵抗性乳腺癌休眠逃逸。
Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E9066-E9075. doi: 10.1073/pnas.1704862114. Epub 2017 Oct 11.
3
NR2F1 controls tumour cell dormancy via SOX9- and RARβ-driven quiescence programmes.NR2F1通过SOX9和RARβ驱动的静止程序控制肿瘤细胞休眠。
Nat Commun. 2015 Jan 30;6:6170. doi: 10.1038/ncomms7170.
4
Ubiquitination in disease pathogenesis and treatment.泛素化在疾病发病机制和治疗中的作用。
Nat Med. 2014 Nov;20(11):1242-53. doi: 10.1038/nm.3739. Epub 2014 Nov 6.
5
TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition.TRIM蛋白调节自噬,并可通过直接识别靶向自噬底物。
Dev Cell. 2014 Aug 25;30(4):394-409. doi: 10.1016/j.devcel.2014.06.013. Epub 2014 Aug 7.
6
Osteoblastic niche supports the growth of quiescent multiple myeloma cells.成骨细胞龛支持静止多发性骨髓瘤细胞的生长。
Blood. 2014 Apr 3;123(14):2204-8. doi: 10.1182/blood-2013-07-517136. Epub 2014 Jan 14.
7
A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance.一种新型小分子去泛素化酶 USP14 和UCHL5 的抑制剂诱导多发性骨髓瘤细胞凋亡并克服硼替佐米耐药。
Blood. 2014 Jan 30;123(5):706-16. doi: 10.1182/blood-2013-05-500033. Epub 2013 Dec 6.
8
A SNP microarray and FISH-based procedure to detect allelic imbalances in multiple myeloma: an integrated genomics approach reveals a wide gene dosage effect.一种用于检测多发性骨髓瘤中等位基因失衡的单核苷酸多态性微阵列和基于荧光原位杂交的方法:一种综合基因组学方法揭示了广泛的基因剂量效应。
Genes Chromosomes Cancer. 2009 Jul;48(7):603-14. doi: 10.1002/gcc.20668.
9
Leukemia and hematopoietic stem cells: balancing proliferation and quiescence.白血病与造血干细胞:平衡增殖与静止
Cell Cycle. 2008 Mar 1;7(5):586-91. doi: 10.4161/cc.7.5.5549. Epub 2008 Jan 1.
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Gene-expression signature of benign monoclonal gammopathy evident in multiple myeloma is linked to good prognosis.多发性骨髓瘤中明显的良性单克隆丙种球蛋白病的基因表达特征与良好预后相关。
Blood. 2007 Feb 15;109(4):1692-700. doi: 10.1182/blood-2006-07-037077. Epub 2006 Oct 5.