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病原体药物盒筛选揭示了抗锥虫病药物研发的新起点。

Screening of the Pathogen Box reveals new starting points for anti-trypanosomal drug discovery.

作者信息

Veale Clinton G L, Hoppe Heinrich C

机构信息

School of Chemistry and Physics , Pietermaritzburg Campus , University of KwaZulu-Natal , Private Bag X01 , Scottsville , 3209 , South Africa . Email:

Department of Biochemistry and Microbiology , Rhodes University , Grahamstown , 6140 , South Africa . Email:

出版信息

Medchemcomm. 2018 Oct 26;9(12):2037-2044. doi: 10.1039/c8md00319j. eCollection 2018 Dec 1.

DOI:10.1039/c8md00319j
PMID:30647879
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6301270/
Abstract

This study aimed to uncover new starting points for anti-trypansomal drug discovery through the screening of the Pathogen Box against . Our study identified compounds , , , and whose activity and selectivity highlighted them as promising candidates with potential for further study and optimisation.

摘要

本研究旨在通过针对布氏锥虫筛选病原体药物盒，揭示抗锥虫药物发现的新起点。我们的研究鉴定出了化合物、、、和，其活性和选择性表明它们是有潜力的候选物，有进一步研究和优化的可能性。

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