Ferlin Francesco, Giannoni Tommaso, Zuliani Alessio, Piermatti Oriana, Luque Rafael, Vaccaro Luigi
Laboratory of Green S.O.C., Dipartimento di Chimica, Biologia e Biotecnologie, Università degli Studi di Perugia, Via Elce di Sotto 8, 06123-, Perugia, Italy.
Departamento de Química Orgánica, Universidad de Córdoba, Edificio Marie Curie (C-3), Carretera Nacional IV-A, Km 396, E14014, Córdoba, Andalucía, Spain.
ChemSusChem. 2019 Jul 5;12(13):3178-3184. doi: 10.1002/cssc.201802359. Epub 2019 Feb 11.
A gold-incorporated SBA-15 catalyst was prepared by a solvent-free ball-milling approach. The catalyst showed high reactivity and selectivity in the reduction of a variety of nitroarenes to anilines operating in absolute EtOH with NaBH as reducing agent. The catalyst was reused in batch conditions over five consecutive runs without any losses of activity or selectivity. Considering the high chemical stability and reusability of the catalytic system, a continuous-flow protocol was also investigated and defined to minimize the generation of waste and optimize the continuous reuse of the catalyst. Benefits of flow conditions were proven by turnover numbers that increased from 47.5 to 1902 and also by the minimization of both leaching (9.5 vs. 1 ppm) and E-factor values (8 vs. 23 in batch).
通过无溶剂球磨法制备了一种负载金的SBA-15催化剂。该催化剂在以NaBH为还原剂、绝对乙醇为溶剂的条件下，将多种硝基芳烃还原为苯胺的反应中表现出高反应活性和选择性。该催化剂在间歇条件下连续重复使用五次，活性和选择性均无任何损失。考虑到催化体系具有高化学稳定性和可重复使用性，还研究并确定了一种连续流动方案，以尽量减少废物产生并优化催化剂的连续重复使用。流动条件的优势通过周转数从47.5增加到1902得到证明，同时浸出（9.5对1 ppm）和E因子值（间歇条件下为8对23）也降至最低。
