Department of Translational Neuroscience, Jing'an District Centre Hospital of Shanghai, State Key Laboratory of Medical Neurobiology & Institutes of Brain Science, Fudan University, Shanghai, China.
Department of Cardiology and Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.
Acta Biochim Biophys Sin (Shanghai). 2019 Feb 1;51(2):204-215. doi: 10.1093/abbs/gmy168.
Stress is a potent risk factor for depression. Chronic stress can exacerbate and induce symptoms of depression. Clinical studies suggested that depressive patients are more likely to develop coronary artery diseases. However, the causal relationship between depression and heart failure progression remains unclear. In this study, we aimed to explore the relevance between stress and heart failure (HF) in a mouse model subjected to chronic restraint stress and left anterior descending coronary artery (LAD) ligation. Mice were restrained for 3 h daily for 21 days and the processes were repeated once 3 months later. After the repeated chronic restraint stress, mice showed dramatically increased immobility time in the forced swim test, indicating a state of despair. Restrained and control mice were further subjected to LAD ligation surgery. Echocardiography was conducted 1 week, 2 weeks, and 1 month afterward. LAD-operated mice showed a significant decrease in the values of left ventricular ejection fraction (LVEF), and there was no difference in the LVEF values between the restrained and control mice. Relevant gene expression, neurotransmitter system, glial activation, and morphology of the heart-brain axis were comprehensively evaluated. We found no overall differences between the restrained and control mice with HF. Our results revealed that the repeated chronic restraint stress may have little effects on the progression of heart failure.
压力是抑郁的一个重要危险因素。慢性压力会加重和诱发抑郁症状。临床研究表明，抑郁患者更容易患冠状动脉疾病。然而，抑郁和心力衰竭进展之间的因果关系仍不清楚。在这项研究中，我们旨在探讨慢性束缚应激和左前降支冠状动脉（LAD）结扎的小鼠模型中应激与心力衰竭（HF）之间的相关性。小鼠每天束缚 3 小时，持续 21 天，3 个月后重复一次。在重复的慢性束缚应激后，强迫游泳试验中小鼠的不动时间明显增加，表明处于绝望状态。束缚和对照小鼠进一步接受 LAD 结扎手术。在手术后 1 周、2 周和 1 个月进行超声心动图检查。LAD 手术的小鼠左心室射血分数（LVEF）值明显下降，束缚和对照小鼠的 LVEF 值没有差异。全面评估相关基因表达、神经递质系统、胶质细胞激活和心脑轴形态。我们发现 HF 束缚组和对照组之间没有总体差异。我们的结果表明，重复的慢性束缚应激可能对心力衰竭的进展影响不大。
