Pick T E
Marrow Transplant Services, Cook-Fort Worth Children's Medical Center, Texas.
Crit Rev Oncol Hematol. 1988;8(4):311-37. doi: 10.1016/s1040-8428(88)80012-x.
Autologous bone marrow transplantation is a procedure that allows for the delivery of high doses of chemotherapy and radiation to treat pediatric malignancies. There have been many studies showing a dose-response curve for many of the drugs that have been used for cytoreductive therapy in autologous bone marrow transplantation. These dosage ranges are achievable in many of the preparative regimens used in autologous bone marrow transplantation. The results in neuroblastoma, Hodgkin's disease, non-Hodgkin's lymphoma, Ewing's sarcoma, rhabdomyosarcoma, osseous sarcoma, other soft tissue sarcomas, and acute leukemias (acute lymphoblastic leukemia and acute non-lymphoblastic leukemia) are reviewed. The question of purging of bone marrow during autologous bone marrow transplantation is addressed. The different techniques of purging are reviewed and the advantages and disadvantages of each are discussed. Finally, new areas of treatment and future directions of autologous bone marrow transplantation are addressed.
自体骨髓移植是一种允许给予高剂量化疗和放疗以治疗儿童恶性肿瘤的程序。有许多研究显示了在自体骨髓移植中用于细胞减灭治疗的许多药物的剂量反应曲线。这些剂量范围在自体骨髓移植中使用的许多预处理方案中是可以实现的。本文综述了神经母细胞瘤、霍奇金病、非霍奇金淋巴瘤、尤因肉瘤、横纹肌肉瘤、骨肉瘤、其他软组织肉瘤以及急性白血病（急性淋巴细胞白血病和急性非淋巴细胞白血病）的治疗结果。文中讨论了自体骨髓移植期间骨髓净化的问题。综述了不同的净化技术，并讨论了每种技术的优缺点。最后，探讨了自体骨髓移植的新治疗领域和未来方向。
