卵母细胞形态对玻璃化冷冻自体卵母细胞解冻后存活和胚胎发育的影响。
Effect of oocyte morphology on post-warming survival and embryo development in vitrified autologous oocytes.
机构信息
Instituto Valenciano de Infertilidad (IVI), University of Valencia, Pl. Policía Local 3, Valencia, Spain.
Instituto Valenciano de Infertilidad (IVI), University of Valencia, Pl. Policía Local 3, Valencia, Spain.
出版信息
Reprod Biomed Online. 2019 Mar;38(3):313-320. doi: 10.1016/j.rbmo.2018.11.028. Epub 2019 Jan 8.
RESEARCH QUESTION
Does the presence of dysmorphisms affect post-warming survival and embryo development in vitrified autologous oocytes?
DESIGN
A retrospective study comparing post-warming survival, fertilization and embryo development between morphologically normal (n = 269) and dysmorphic oocytes (n = 147).
RESULTS
The survival rate was 81.4% in the morphologically normal oocytes and 87.1% in the dysmorphic oocyte group (OR 1.53; 95% CI 0.86 to 2.72). The fertilization rate was 69.9 versus 66.4% (OR 0.85; 95% CI 0.53 to 1.36), the proportion of good-quality embryos on day 3 was 30.3% versus 32.0% (OR 1.08; 95% CI 0.59 to 1.97) and the blastocyst formation rate was 54.5% versus 60.5% (OR 1.27; 95% CI 0.60 to 2.72) for the morphologically normal and the dysmorphic oocytes group, respectively. No statistical differences were found when the number and type of dysmorphism were analysed.
CONCLUSION
Oocyte dysmorphisms did not seem to affect survival, fertilization and embryo development in vitrified autologous oocytes, and yielded comparable results to the morphologically normal oocytes.
研究问题
畸形是否会影响玻璃化自体卵母细胞解冻后的存活和胚胎发育？
设计
一项回顾性研究比较了形态正常的卵母细胞（n=269）和畸形卵母细胞（n=147）在解冻后存活、受精和胚胎发育情况。
结果
形态正常卵母细胞的存活率为 81.4%，畸形卵母细胞组为 87.1%（OR 1.53；95%CI 0.86 至 2.72）。受精率分别为 69.9%和 66.4%（OR 0.85；95%CI 0.53 至 1.36），第 3 天优质胚胎比例分别为 30.3%和 32.0%（OR 1.08；95%CI 0.59 至 1.97），囊胚形成率分别为 54.5%和 60.5%（OR 1.27；95%CI 0.60 至 2.72）。当分析畸形的数量和类型时，没有发现统计学差异。
结论
卵母细胞畸形似乎不会影响玻璃化自体卵母细胞的存活、受精和胚胎发育，并且与形态正常的卵母细胞产生相当的结果。
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