Plasma cell dyscrasias.

In this article we have discussed the usefulness and limitations of the bone marrow examination in the differential diagnosis of the plasma cell dyscrasias. Because of the overlapping clinical and morphologic features encountered with these disorders and problems due to random marrow sampling, the difficulties in making a correct bone marrow interpretation may be quite formidable. The applicability of immunohistochemistry has been discussed and the need for clinical correlation emphasized.